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TEMPOL-H

Known as: HOTMP, 4-hydroxy-2,2,6,6-tetramethyl-1-hydroxypiperidine, 4-hydroxy-TEMPO 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Cyclic N-OxidesHydroxylamine

Narrower (1)

OT-674

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Inhibition of the chlorinating activity of myeloperoxidase by tempol: revisiting the kinetics and mechanisms.
The nitroxide tempol (4-hydroxy-2,2,6,6-tetramethyl piperidine-1-oxyl) reduces tissue injury in animal models of inflammation by… Expand
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2008
2008
Role of oxidant stress on AT1 receptor expression in neurons of rabbits with heart failure and in cultured neurons.
We have previously reported that the expression of Angiotensin II (Ang II) type 1 receptors (AT1R) was increased in the rostral… Expand
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2008
2008
Formation of TEMPOL-hydroxylamine during reaction between TEMPOL and hydroxyl radical: HPLC/ECD study
Nitroxyl radicals are important antioxidants that have been used to protect animal tissues from oxidative damage. Their reaction… Expand
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2007
2007
Role of NADPH oxidase and ANG II in diabetes-induced retinal leukostasis.
We studied whether angiotensin II (ANG II) via superoxide may contribute to retinal leukostasis and thus to the pathogenesis of… Expand
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2006
2006
Local treatment of experimental colitis in the rat by negatively charged liposomes of catalase, TMN and SOD
Superoxide dismutase (SOD), 4-amino tempol (tempamine, denoted as TMN) and catalase were encapsulated into negatively charged… Expand
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2004
2004
Central Tempol alters basal sympathetic nerve discharge and attenuates sympathetic excitation to central ANG II.
In the present study, we established dose-response relationships between central administration of 4-hydroxy-2,2,6,6… Expand
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2004
2004
4-Hydroxy tempol-induced impairment of mitochondrial function and augmentation of glucose transport in vascular endothelial and smooth muscle cells.
The water-soluble and cell permeable nitroxide derivative 4-hydroxy tempol (TPL) has been shown to reduce or ameliorate oxidative… Expand
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2002
2002
Early antioxidant therapy with Tempol during hemorrhagic shock increases survival in rats.
BACKGROUND Hemorrhagic shock (HS) is associated with the generation of reactive oxygen species, which may contribute to delayed… Expand
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Highly Cited
2001
Highly Cited
2001
Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity.
Although arsenic is a well-established human carcinogen, the mechanisms by which it induces cancer remain poorly understood. We… Expand
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Highly Cited
1992
Highly Cited
1992
Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide.
Dismutation of superoxide has been shown previously to be catalyzed by stable nitroxide compounds. In the present study, the… Expand
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