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TCV 309
Known as:
TCV-309
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (3)
Platelet Aggregation Inhibitors
Pyridinium Compounds
Tetrahydroisoquinolines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice
Katsuya Morita
,
Norimitsu Morioka
,
Joynal Abdin
,
Shigeo Kitayama
,
Toshihiro Dohi
Pain
2004
Platelet-activating factor (PAF) is a potent inflammatory lipid mediator in peripheral tissues. However, its role in mediation of…
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2000
2000
Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet-activating factor antagonist TCV-309: a prospective, multicenter, double-blind, randomized phase II…
Martijn Poeze
,
A H Froon
,
Graham Ramsay
,
Wim A. Buurman
,
Jan Willem M. Greve
Shock
2000
Sepsis and organ failure remain the main cause of death on the ICU. Sepsis is characterized by a severe inflammatory response, in…
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1999
1999
Platelet-activating factor antagonist (TCV-309) attenuates the priming effects of bronchoalveolar macrophages in cerulein-induced pancreatitis rats.
Yu Yamaguchi
,
Fujio Matsumura
,
+7 authors
Michio Ogawa
Pancreas
1999
We investigated the role of platelet-activating factor (PAF) as a priming signal for cytokine-induced neutrophil chemoattractant…
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1998
1998
Triple role of platelet-activating factor in eosinophil migration across monolayers of lung epithelial cells: eosinophil chemoattractant and priming agent and epithelial cell activator.
Lu-ning Liu
,
A E Zuurbier
,
+4 authors
David Roos
Journal of immunology
1998
Infiltration of eosinophils into the lung lumen is a hallmark of allergic asthmatic inflammation. To reach the lung lumen…
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1996
1996
Treatment with the platelet-activating factor antagonist TCV-309 in patients with severe systemic inflammatory response syndrome: a prospective, multi-center, double-blind, randomized phase II trial.
A M Froon
,
Jan Willem M. Greve
,
+4 authors
Marc Bourgeois
Shock
1996
In a prospective randomized, double-blind, placebo-controlled clinical study, the safety and efficacy of the platelet-activating…
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1993
1993
Effect of the platelet-activating factor antagonist, TCV-309, and the cyclo-oxygenase inhibitor, ibuprofen, on the haemodynamic changes in canine experimental endotoxic shock.
Shigeo Yamanaka
,
Hiroshi Iwao
,
Tokihito Yukimura
,
S Kim
,
Katsuhiro Miura
British journal of pharmacology
1993
1. The present study was conducted in order to examine the effects of the platelet-activating factor (PAF) antagonist, TCV-309…
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1993
1993
Role of platelet activating factor in ischaemia-reperfusion injury of isolated rabbit hearts: protective effect of a specific platelet activating factor antagonist, TCV-309.
Shuji Katoh
,
Junji Toyama
,
Itsuo Kodama
,
Akihiko Koike
,
Toshio Abe
Cardiovascular research
1993
OBJECTIVES The aims were to confirm that platelet activating factor is released during reperfusion after global ischaemia in…
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1992
1992
Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents.
Zenichi Terashita
,
Mitsutoshi Kawamura
,
Masahiro Takatani
,
Susumu Tsushima
,
Yoshimi Imura
,
Kohki Nishikawa
The Journal of pharmacology and experimental…
1992
Pharmacological profiles of a novel specific platelet activating factor (PAF) antagonist, TCV-309 (3-bromo-5-[N-phenyl-N-[2-[2…
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1992
1992
Pharmacological profile of TCV-309--a potent PAF antagonist.
Zenichi Terashita
,
Masahiro Takatani
,
Kazuhiro Nishikawa
Journal of lipid mediators
1992
TCV-309 potently and specifically inhibited the diverse biological actions of PAF such as platelet aggregation, hypotension…
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1992
1992
Role of platelet activating factor in pathogenesis of acute pancreatitis in rats.
Stanisław Jan Konturek
,
Artur Dembiński
,
+5 authors
Jerzy Stachura
Gut
1992
The importance of platelet activating factor in acute pancreatitis was examined by determining the tissue content of endogenous…
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