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TCV 309
Known as:
TCV-309
National Institutes of Health
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Related topics
Related topics
3 relations
Broader (3)
Platelet Aggregation Inhibitors
Pyridinium Compounds
Tetrahydroisoquinolines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice
K. Morita
,
N. Morioka
,
Joynal Abdin
,
S. Kitayama
,
T. Dohi
Pain
2004
Corpus ID: 17965941
Abstract Platelet‐activating factor (PAF) is a potent inflammatory lipid mediator in peripheral tissues. However, its role in…
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Highly Cited
2000
Highly Cited
2000
Decreased organ failure in patients with severe SIRS and septic shock treated with the platelet-activating factor antagonist TCV-309: a prospective, multicenter, double-blind, randomized phase II…
M. Poeze
,
A. H. Froon
,
G. Ramsay
,
W. Buurman
,
J. W. Greve
Shock
2000
Corpus ID: 5987583
Sepsis and organ failure remain the main cause of death on the ICU. Sepsis is characterized by a severe inflammatory response, in…
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1998
1998
Triple role of platelet-activating factor in eosinophil migration across monolayers of lung epithelial cells: eosinophil chemoattractant and priming agent and epithelial cell activator.
L. Liu
,
A. Zuurbier
,
+4 authors
D. Roos
Journal of immunology
1998
Corpus ID: 25883771
Infiltration of eosinophils into the lung lumen is a hallmark of allergic asthmatic inflammation. To reach the lung lumen…
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1997
1997
Extended lung preservation with platelet-activating factor-antagonist TCV-309 in combination with prostaglandin E1.
A. Qayumi
,
J. English
,
+5 authors
G. Fradet
The Journal of heart and lung transplantation…
1997
Corpus ID: 22341222
BACKGROUND Ischemia-reperfusion injury is one of the major problems in organ transplantation. The role of platelet-activating…
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1996
1996
TREATMENT WITH THE PLATELET-ACTIVATING FACTOR ANTAGONIST TCV-309 IN PATIENTS WITH SEVERE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME: A PROSPECTIVE, MULTI-CENTER, DOUBLEBLIND, RANDOMIZED PHASE II TRIAL;
A. Froon
,
J. W. Greve
,
+4 authors
M. Bourgeois
Shock
1996
Corpus ID: 20076226
In a prospective randomized, double-blind, placebo-controlled clinical study, the safety and efficacy of the platelet-activating…
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Highly Cited
1994
Highly Cited
1994
Platelet-activating factor antagonist TCV-309 attenuates the induction of the cytokine network in experimental endotoxemia in chimpanzees.
B. Kuipers
,
T. van der Poll
,
+5 authors
J. T. ten Cate
Journal of immunology
1994
Corpus ID: 6499385
Platelet-activating factor (PAF) has been postulated to play a role in the pathogenesis of sepsis. Additionally, in vitro studies…
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1993
1993
Effect of the platelet‐activating factor antagonist, TCV‐309, and the cyclo‐oxygenase inhibitor, ibuprofen, on the haemodynamic changes in canine experimental endotoxic shock
S. Yamanaka
,
H. Iwao
,
T. Yukimura
,
S. Kim
,
K. Miura
British journal of pharmacology
1993
Corpus ID: 2264698
1 The present study was conducted in order to examine the effects of the platelet‐activating factor (PAF) antagonist, TCV‐309…
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Highly Cited
1992
Highly Cited
1992
Beneficial effects of TCV-309, a novel potent and selective platelet activating factor antagonist in endotoxin and anaphylactic shock in rodents.
Z. Terashita
,
M. Kawamura
,
M. Takatani
,
S. Tsushima
,
Y. Imura
,
K. Nishikawa
The Journal of pharmacology and experimental…
1992
Corpus ID: 32705466
Pharmacological profiles of a novel specific platelet activating factor (PAF) antagonist, TCV-309 (3-bromo-5-[N-phenyl-N-[2-[2…
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1992
1992
Pharmacological profile of TCV-309--a potent PAF antagonist.
Z. Terashita
,
M. Takatani
,
K. Nishikawa
Journal of lipid mediators
1992
Corpus ID: 23098492
TCV-309 potently and specifically inhibited the diverse biological actions of PAF such as platelet aggregation, hypotension…
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Highly Cited
1992
Highly Cited
1992
Role of platelet activating factor in pathogenesis of acute pancreatitis in rats.
S. Konturek
,
A. Dembiński
,
+5 authors
J. Stachura
Gut
1992
Corpus ID: 2731879
The importance of platelet activating factor in acute pancreatitis was examined by determining the tissue content of endogenous…
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