TCV 309

Abstract Platelet‐activating factor (PAF) is a potent inflammatory lipid mediator in peripheral tissues. However, its role in… Expand

Sepsis and organ failure remain the main cause of death on the ICU. Sepsis is characterized by a severe inflammatory response, in… Expand

Infiltration of eosinophils into the lung lumen is a hallmark of allergic asthmatic inflammation. To reach the lung lumen… Expand

BACKGROUND Ischemia-reperfusion injury is one of the major problems in organ transplantation. The role of platelet-activating… Expand

In a prospective randomized, double-blind, placebo-controlled clinical study, the safety and efficacy of the platelet-activating… Expand

Platelet-activating factor (PAF) has been postulated to play a role in the pathogenesis of sepsis. Additionally, in vitro studies… Expand

1 The present study was conducted in order to examine the effects of the platelet‐activating factor (PAF) antagonist, TCV‐309… Expand

Pharmacological profiles of a novel specific platelet activating factor (PAF) antagonist, TCV-309 (3-bromo-5-[N-phenyl-N-[2-[2… Expand

TCV-309 potently and specifically inhibited the diverse biological actions of PAF such as platelet aggregation, hypotension… Expand

The importance of platelet activating factor in acute pancreatitis was examined by determining the tissue content of endogenous… Expand