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TCR signalosome

Known as: LAT signalosome, linker for activation of T cells signalosome 
A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also… 
National Institutes of Health

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T-cell receptor complex location

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
TCR signalling in response to affinity stimulation
T cells are an essential part of the adaptive immune system and protect the body from intracellular infections. The specificity… 
2012
2012
A Conserved Motif in the ITK PH-Domain Is Required for Phosphoinositide Binding and TCR Signaling but Dispensable for Adaptor Protein Interactions
Binding of the membrane phospholipid phosphatidylinositol 3,4,5-trisphosphate (PIP3) to the Pleckstrin Homology (PH) domain of… 
Review
2010
Review
2010
Lymphoproliferative disorders involving T helper effector cells with defective LAT signalosomes
Linker for activation of T cells (LAT) is a membrane adaptor protein that is expressed in T cells and coordinates the assembly of… 
Review
2007
Review
2007
Th2 lymphoproliferative disorders resulting from defective LAT signalosomes.
LAT (linker for activation of T cells) is an integral membrane adaptor protein that constitutes in T cells a major substrate of… 
Review
2006
Review
2006
PKCtheta: A potential therapeutic target for T-cell-mediated diseases.
Protein kinase (PK)Ctheta belongs to the calcium-independent novel subfamily of PKCs, which itself is a member of the cAMP… 
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