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TCPOBOP

 
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Obesity and type 2 diabetes are related metabolic disorders of high prevalence. The constitutive androstane receptor (CAR) was… Expand
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Review
2006
Review
2006
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are members of the nuclear receptor superfamily. These… Expand
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Highly Cited
2005
Highly Cited
2005
The multidrug resistance-associated proteins (Mrp) are ATP-dependent transporters that export a variety of conjugated and… Expand
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Highly Cited
2004
Highly Cited
2004
ABSTRACT The nuclear receptors CAR and PXR activate hepatic genes in response to therapeutic drugs and xenobiotics, leading to… Expand
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Highly Cited
2003
Highly Cited
2003
Pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are key regulators of xenobiotic-inducible cytochrome P450… Expand
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Highly Cited
2003
Highly Cited
2003
The nuclear receptors, farnesoid X receptor (FXR) and pregnane X receptor (PXR), are important in maintaining bile acid… Expand
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2003
2003
The nuclear receptor Constitutive Androstane Receptor (CAR) binds DNA as a heterodimer with the retinoic-X receptor and activates… Expand
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Highly Cited
2002
Highly Cited
2002
The products of the cytochrome P450 (CYP) genes play an important role in the detoxification of xenobiotics and environmental… Expand
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Highly Cited
2000
Highly Cited
2000
Organisms encounter a wide range of foreign compounds—or ‘xenobiotics’—with potentially harmful consequences. The cytochrome P450… Expand
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Highly Cited
2000
Highly Cited
2000
ABSTRACT A wide range of xenobiotic compounds are metabolized by cytochrome P450 (CYP) enzymes, and the genes that encode these… Expand
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