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TC 2559

Known as: (E)-N-methyl-4-(3-(5-ethoxypyridin)yl)-3-buten-1-amine, TC-2559, TC2559 
National Institutes of Health

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Broader (1)

Pyridines

Papers overview

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2016
2016
Lithium Enolates Derived from Pyroglutaminol: Mechanism and Stereoselectivity of an Azaaldol Addition.
A lithium enolate derived from an acetonide-protected pyroglutaminol undergoes a highly selective azaaldol addition with (E)-N… 
2015
2015
Peripheral alpha4beta2 nicotinic acetylcholine receptor signalling attenuates tactile allodynia and thermal hyperalgesia after nerve injury in mice
Neuropathic pain is often refractory to conventional analgesics including opioids and non‐steroidal anti‐inflammatory drugs… 
2014
2014
Non-equivalent Ligand Selectivity of Agonist Sites in (α4β2)2α4 Nicotinic Acetylcholine Receptors
Background: The α4/β2 and α4/α4 interfaces of the (α4β2)2α4 nicotinic acetylcholine receptor house structurally different agonist… 
2013
2013
Base and solvent dependency of an oxidative retro-alkylation of secondary and tertiary benzylamines
An iodine and caesium carbonate amine oxidation protocol is described. Non-branched secondary benzylamines were cleanly oxidised… 
2011
2011
Enhanced inhibitory synaptic transmission in the spinal dorsal horn mediates antinociceptive effects of TC-2559
BackgroundTC-2559 is a selective α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist and α4β2 nAChR… 
2006
2006
TC‐2559 excites dopaminergic neurones in the ventral tegmental area by stimulating α4β2‐like nicotinic acetylcholine receptors in anaesthetised rats
The in vivo effects of a selective partial agonist for neuronal nicotinic acetylcholine receptor (nAChRs) α4β2 subtype, TC‐2559… 
2006
2006
5-I A-85380 and TC-2559 differentially activate heterologously expressed alpha4beta2 nicotinic receptors.
The neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits expressed in heterologous expression systems assemble… 
2006
2006
The alpha4beta2 nicotinic acetylcholine receptor agonist TC-2559 impairs long-term potentiation in the dentate gyrus in vivo.
Nicotinic acetylcholine receptors (nAChR) are widely expressed throughout the nervous system, are involved in some fast… 
2003
2003
The nicotinic alpha 4 beta 2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices.
The ability of alpha4beta2 nicotinic acetylcholine receptors to modulate dopaminergic (DA) cell activity in the ventral tegmental… 
2000
2000
TC-2559: a novel orally active ligand selective at neuronal acetylcholine receptors.
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