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TAS 103

Known as: 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one dihydrochloride, TAS-103 
A quinoline derivative that inhibits both topoisomerase I and II, causing a cytotoxic effect in cancer cells. (NCI)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Blood antioxidant status, dysglycemia and obstructive sleep apnea.
Obstructive sleep apnea (OSA) patients present increased cardiovascular morbidity and mortality. Oxidative stress is involved in… 
2008
2008
Maximum Size and Throughput of SOA-Based Optical Burst Switching Nodes With Limited Tuning-Range Wavelength Converters and FDL Buffers
In this paper, we show the physical limitations of semiconductor optical amplifier (SOA)-based switching nodes for optical burst… 
2007
2007
Promising antitumor activity of a novel quinoline derivative, TAS-103, against fresh clinical specimens of eight types of tumors measured by flow cytometric DNA analysis.
TAS-103, 6-[[2-(dimethylamino)ethyl]amino]-3-hydroxy-7H-indeno-[2,1-c]quinolin-7-one dihydrochloride, is a dual topoisomerases I… 
2005
2005
DNA Topoisomerase II Poison TAS-103 Transactivates GC-Box-dependent Transcription via Acetylation of Sp1*
Drug-induced modifications of transcription factors play important roles in both apoptosis and survival signaling. The data… 
2001
2001
Phase I clinical and pharmacogenetic study of weekly TAS-103 in patients with advanced cancer.
PURPOSE TAS-103 is an inhibitor of both topoisomerase I and II enzymes with broad antitumor activity. It is metabolized to TAS… 
Highly Cited
1999
Highly Cited
1999
DNA topoisomerases as targets for the anticancer drug TAS-103: DNA interactions and topoisomerase catalytic inhibition.
TAS-103 is a novel anticancer drug that kills cells by increasing levels of DNA cleavage mediated by topoisomerase II. While most… 
1999
1999
Hetero [4 + 2] cycloadditions of (trialkylsilyl)vinylketenes. Synthesis of alpha,beta-unsaturated delta-valerolactones and -lactams.
[formula: see text] Hetero Diels-Alder reactions of (trialkylsilyl)vinylketenes (TAS-vinylketenes) with carbonyl and imino… 
1999
1999
Morphometric analysis of bromodeoxyuridine distribution and cell density in the rat Dunning prostate tumor R3327-AT1 following treatment with radiation and/or hyperthermia.
To monitor cellular response to single doses of radiation (RT) and/or local tumor hyperthermia (LTH) proliferation kinetics were… 
Highly Cited
1960
Highly Cited
1960
The effect of human fibrinolysin on pulmonary metastases of Walker 256 carcinosarcoma.
Summary 1.A significant in vitro fibrinolytic activity could be obtained in plasma of rats given human fibrinolysin intravenously… 
1953
1953
Metastatic frequency of spontaneous mammary carcinoma in mice following biopsy and following local roentgen irradiation.
Summary Local roentgen irradiation of spontaneous mammary carcinomas in DBA mice with doses of 1,000–2,000 r considerably… 
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