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Antitumor activity of mitoxantrone against murine experimental tumors: Comparative analysis against various antitumor antibiotics
Summary1,4-Dihydroxy-5,8-bis{{{{2-[(2-hydroxyethyl)amino]ethyl}amino}}-9,10-anthracenedione dihydrochloride (mitoxantrone) was tested for antitumor activity against experimental tumors in mice andExpand
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Association of p53 gene mutation with decreased chemosensitivity in human malignant gliomas
Loss of p53 function is involved in tumorigenesis of various human cancers, but the relation between mutation of the p53 tumor‐suppressor gene and the chemo‐ and radiosensitivity of tumors remainsExpand
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Effect of drug combination of antitumor activity and myelotoxicity.
Relationship between the survival time of L-1210-bearing mice and myelosuppression of normal mice after combination chemotherapy was studied. In a variety of combinations of 6-mercaptopurine,Expand
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Combination chemotherapy of 6-thioguanine with various antitumor agents against murine leukemia L-1210.
Antitumor activity of 6-thioguanine against L-1210 leukemia was studied in combination with various antitumor agents in clinical stages, such as mitomycin-C, carbazilquinone, cyclophosphamide,Expand
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[Schedule dependency of i.v.-paclitaxel against SC-M 109 mouse lung cancer].
  • S. Fujimoto
  • Medicine
  • Gan to kagaku ryoho. Cancer & chemotherapy
  • 1 April 1994
Although paclitaxel was shown to have a broad spectrum of antitumor activity against various experimental tumors, the optimal treatment schedule of this drug is not yet determined. In the presentExpand
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[Study for modifying activity of solvents on antitumor activity of paclitaxel].
  • S. Fujimoto
  • Medicine
  • Gan to kagaku ryoho. Cancer & chemotherapy
  • 1 April 1994
Paclitaxel, a novel diterpenoid compound, has been used by dissolving in Cremophor EL (polyoxyethylene castor oil) due to its poor aqueous solubility. Cremophor EL was shown to reverse multidrugExpand
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Thermochromic Properties of Flavylium Salts in Agar-Gel Matrix
Flavylium salts exhibited a reversible thermochromism in an agar-gel matrix. Thus, by the temperature change from −3 to 50 °C, the absorption band around 600 nm ofExpand
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Antitumor activity of polymorphonuclear leukocytes activated by a beta-1,3-D-glucan.
The antitumor activity of mouse polymorphonuclear leukocyte (PMN) treated with a beta-1,3-D-glucan from Alcaligenes faecalis var. myxogenes IFO 13140 (TAK-N) and its carboxymethylated derivativeExpand
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Selection of chemotherapy for glioblastoma expressing O(6)-methylguanine-DNA methyltransferase.
The therapeutic benefit of nitrosoureas or temozolomide for glioblastoma is limited mainly by O(6)-methylguanine-DNA methyltransferase (MGMT) expression. The aim of this study was to evaluate theExpand
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Albumin microspheres as drug carriers.
In order to improve the therapeutic index in cancer chemotherapy, it is necessary to deliver antitumor agents to target sites (tumor sites). One of the methods used to deliver those agents to targetExpand
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