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In most mammals, the MHC class I molecules are polymorphic and determine the specificity of peptide presentation, whereas the… Expand The basis for strong immunogenetic associations between particular human leukocyte antigen (HLA) class I allotypes and… Expand BACKGROUND
Imiquimod is a local immune response modifier that has demonstrated potent antiviral and antitumor activity. It… Expand Oncolytic herpes simplex virus type 1 (HSV-1) vectors are promising therapeutic agents for cancer. Their efficacy depends on the… Expand Bone marrow–derived antigen-presenting cells (APCs) take up cell-associated antigens and present them in the context of major… Expand ABSTRACT Herpes simplex virus serotype 1 (HSV-1) expresses an immediate-early protein, ICP47, that effectively blocks the major… Expand The herpes simplex virus (HSV) infected cell protein (ICP)47 blocks CD8+ T cell recognition of infected cells by inhibiting the… Expand BALB/c mice vaccinated with vaccinia virus expressing the major surface glycoprotein G of respiratory syncytial virus (RSV… Expand The herpes simplex virus (HSV) ICP47 protein inhibits the MHC class I antigen presentation pathway by inhibiting the transporter… Expand Malignant tumor cells can escape CD8+ cytotoxic T cell killing by downregulating class I major histocompatibility complex (MHC… Expand