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TAK-875

National Institutes of Health

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Related topics

3 relations

Broader (2)

BenzofuransSulfones

Narrower (1)

fasiglifam

Papers overview

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2019
2019
Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold.
2019
2019
Disposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humans
Abstract The absorption, distribution, metabolism, and excretion of fasiglifam were investigated in rats, dogs, and humans. The… 
2019
2019
Design, synthesis and biological evaluation of novel FFA1/GPR40 agonists: New breakthrough in an old scaffold.
2019
2019
Pharmacokinetics of TAK-875 and its toxic metabolite TAK-875- acylglucuronide in rat plasma by liquid chromatography tandem mass spectrometry.
TAK-875 is a selective partial agonist of human GPR40 receptor, which was unexpectedly terminated at phase III clinical trials… 
2019
2019
Design, synthesis and biological activity of deuterium-based FFA1 agonists with improved pharmacokinetic profiles.
2018
2018
Nitric oxide donor-based FFA1 agonists: Design, synthesis and biological evaluation as potential anti-diabetic and anti-thrombotic agents.
2018
2018
Discovery of a novel potent GPR40 full agonist.
2018
2018
Design, synthesis and biological evaluation of a series of novel GPR40 agonists containing nitrogen heterocyclic rings.
2015
2015
Free fatty acid receptors: structural models and elucidation of ligand binding interactions
BackgroundThe free fatty acid receptors (FFAs), including FFA1 (orphan name: GPR40), FFA2 (GPR43) and FFA3 (GPR41) are G protein… 
2012
2012
Could FFAR1 assist insulin secretion in type 2 diabetes?
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