Skip to search formSkip to main contentSkip to account menu

TAK 779

Known as: N-((4-(((6,7-dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl)carbonyl)amino)phenyl)methyl)tetrahydro-N,N-dimethyl-2H-pyran-4-aminium chloride, TAK-779 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

AmidesCCR5 Receptor AntagonistsQuaternary Ammonium Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Synthesis of thiophene-based TAK-779 analogues by C-H arylation.
A rapid synthesis of thiophene-based TAK-779 analogues 1 is reported using a late-stage diversification strategy. At the end of… 
2011
2011
Allosteric and Orthosteric Sites in CC Chemokine Receptor (CCR5), a Chimeric Receptor Approach*
Background: Characterization of 7TM biology and chemistry is needed generally and within chemokine receptors. Results: A CCR5… 
2009
2009
The chemokine receptor antagonist, TAK‐779, decreased experimental autoimmune encephalomyelitis by reducing inflammatory cell migration into the central nervous system, without affecting T cell…
Background and purpose:  The C–C chemokine receptor CCR5, and the C–X–C chemokine receptor CXCR3 are involved in the regulation… 
2008
2008
Altered sensitivity of an R5X4 HIV-1 strain 89.6 to coreceptor inhibitors by a single amino acid substitution in the V3 region of gp120.
2008
2008
Effects of Blocking the Chemokine Receptors, CCR5 and CXCR3, With TAK-779 in a Rat Small Intestinal Transplantation Model
Background. The effect of blocking lymphocyte chemokine receptors with TAK-779 was investigated using a rat intestinal… 
2007
2007
The envelope gene is a cytopathic determinant of CCR5 tropic HIV-1.
2007
2007
Betulinic Acid Derivatives That Target gp120 and Inhibit Multiple Genetic Subtypes of Human Immunodeficiency Virus Type 1
ABSTRACT Betulinic acid (BA) derivatives can inhibit human immunodeficiency virus type 1 (HIV-1) entry or maturation depending on… 
2006
2006
An anti-CCR5 monoclonal antibody and small molecule CCR5 antagonists synergize by inhibiting different stages of human immunodeficiency virus type 1 entry.
Highly Cited
2002
Highly Cited
2002
A pivotal role for CC chemokine receptor 5 in T-cell migration to tumor sites induced by interleukin 12 treatment in tumor-bearing mice.
Interleukin (IL) 12 treatment in the CSA1M and OV-HM, but not in Meth A tumor models,induces tumor regression that is associated… 
2001
2001
TAK-779 (Takeda).
TAK-779 is a CCR5 antagonist under investigation by Takeda and Kagoshima University for the potential treatment of HIV [324663… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)