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TAK 779

Known as: N-((4-(((6,7-dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl)carbonyl)amino)phenyl)methyl)tetrahydro-N,N-dimethyl-2H-pyran-4-aminium chloride, TAK-779 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

AmidesCCR5 Receptor AntagonistsQuaternary Ammonium Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Inhibition of HIV fusion with multivalent gold nanoparticles.
The design and synthesis of a multivalent gold nanoparticle therapeutic is presented. SDC-1721, a fragment of the potent HIV… 
Highly Cited
2006
Highly Cited
2006
Expression of CCL5 (RANTES) and CCR5 in prostate cancer
Expression of the inflammatory chemokine CCL5 (RANTES) by tumor cells is thought to correlate with the progression of several… 
Highly Cited
2006
Highly Cited
2006
Analyzing ligand and small molecule binding activity of solubilized GPCRs using biosensor technology.
Highly Cited
2006
Highly Cited
2006
HIV-1 tropism for the central nervous system: Brain-derived envelope glycoproteins with lower CD4 dependence and reduced sensitivity to a fusion inhibitor.
Highly Cited
2005
Highly Cited
2005
Uncoupling coreceptor usage of human immunodeficiency virus type 1 (HIV-1) from macrophage tropism reveals biological properties of CCR5-restricted HIV-1 isolates from patients with acquired…
Highly Cited
2005
Highly Cited
2005
CCL3 (MIP-1alpha) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2.
Highly Cited
2001
Highly Cited
2001
New developments in anti-HIV chemotherapy
Review
2000
Review
2000
Chemokine receptors and mechanisms of cell death in HIV neuropathogenesis.
Several chemokine receptors are used as coreceptors for HIV-1 entry in the central nervous system (CNS). CCR5 is the major… 
Highly Cited
2000
Highly Cited
2000
Use of Inhibitors To Evaluate Coreceptor Usage by Simian and Simian/Human Immunodeficiency Viruses and Human Immunodeficiency Virus Type 2 in Primary Cells
ABSTRACT We have used coreceptor-targeted inhibitors to investigate which coreceptors are used by human immunodeficiency virus… 
Highly Cited
1999
Highly Cited
1999
A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity.
The beta-chemokine receptor CCR5 is considered to be an attractive target for inhibition of macrophage-tropic (CCR5-using or R5… 
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