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TAK 778

Known as: TAK-778 
National Institutes of Health

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Broader (1)

Benzothiepins

Papers overview

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2011
2011
TAK-778 induces osteogenesis in ovariectomized rats via an estrogen receptor-dependent pathway
TAK-778, a derivative of ipriflavone, has been shown to induce bone growth both in vitro and in vivo. Recently, it has been shown… 
2009
2009
Ex Vivo Comparison of Microbicide Efficacies for Preventing HIV-1 Genomic Integration in Intraepithelial Vaginal Cells
ABSTRACT Vaginally applied microbicides hold promise as a strategy to prevent sexual HIV transmission. Several nonspecific… 
2009
2009
The Effect of TAK-778 on Gene Expression of Osteoblastic Cells Is Mediated Through Estrogen Receptor
This study evaluated the effect of TAK-778 [(2R, 4S)-(−)-N-(4-diethoxyphosphorylmethylphenyl)-1,2,4,5-tetrahydro-4-methyl-7,8… 
2006
2006
Effect of Microcapsules Containing TAK-778 on Bone Formation Around Osseointegrated Implants: Histomorphometric Analysis in Dogs
Purpose:The aim of this study was to evaluate the in vivo effect of TAK-778 on osseointegration of titanium implants. Materials… 
2006
2006
Participation of estrogen receptors in the enhancement of osteoblast differentiation by TAK-778
TAK-778 has been shown to stimulate osteogenesis both in vitro and in vivo. However, the mechanism by which TAK-778 exerts its… 
2003
2003
TAK-778 enhances osteoblast differentiation of human bone marrow cells cultured on titanium.
2002
2002
Enhancement of osteogenesis in vitro by a novel osteoblast differentiation-promoting compound, TAK-778, partly through the expression of Msx2.
2001
2001
Bone bonding in sintered hydroxyapatite combined with a new synthesized agent, TAK-778.
We studied the stimulatory effects of TAK-778, a new synthetic 3-benzothiepin derivative that promotes osteoblast differentiation… 
2001
2001
Sustained-release microcapsules of a bone formation stimulant, TAK-778, for local injection into a fracture site.
The benzothiepin derivative (2R,4S)-(-)-N-(4-diethoxyphosphorylmethylphenyl)-1,2,4,5-tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo… 
1999
1999
A one-step enzyme-linked immunosorbent assay for a novel osteoblast differentiation-promoting compound, TAK-778 in serum.
TAK-778, ((2R,4S)-(-)-N-[(4-diethoxyphosphorylmethyl)phenyl]- 1,2,4,5-tetrahydro-4-methyl-7,8-methylenedioxy-5-oxo-3-benzothiepin… 
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