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TAK-683

National Institutes of Health

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Metastin

Papers overview

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2018
2018
Evaluation of pharmacokinetics/pharmacodynamics and efficacy of one‐month depots of TAK‐448 and TAK‐683, investigational kisspeptin analogs, in male rats and an androgen‐dependent prostate cancer…
2017
2017
An administration of TAK-683 at a minimally effective dose for luteinizing hormone stimulation under the absence of the ovary induces luteinizing hormone surge in ovary-intact goats
The present study aimed to evaluate hormonal responses and their association with the TAK-683 blood concentrations in goats… 
2017
2017
Effect of investigational kisspeptin/metastin analog, TAK-683, on luteinizing hormone secretion at different stages of the luteal phase in goats
This study aimed to examine the response of luteinizing hormone (LH) secretion and ovarian steroid profile to TAK-683, an… 
2016
2016
Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac-d-Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2 (TAK-448), with Highly Potent Testosterone…
Metastin/kisspeptin is an endogenous ligand of KISS1 Receptor (KISS1R). Metastin and KISS1R are suggested to play crucial roles… 
2015
2015
Differential changes in luteinizing hormone secretion after administration of the investigational metastin/kisspeptin analog TAK-683 in goats.
2014
2014
Ovarian and hormonal responses to follicular phase administration of investigational metastin/kisspeptin analog, TAK-683, in goats.
This study evaluated the effects of follicular phase administration of TAK-683, an investigational metastin/kisspeptin analog, on… 
2014
2014
Pharmacologic profiles of investigational kisspeptin/metastin analogues, TAK-448 and TAK-683, in adult male rats in comparison to the GnRH analogue leuprolide.
2013
2013
Differential Effects of Continuous Exposure to the Investigational Metastin/Kisspeptin Analog TAK-683 on Pulsatile and Surge Mode Secretion of Luteinizing Hormone in Ovariectomized Goats
Abstract The aim of the present study was to determine if the estradiol-induced luteinizing hormone (LH) surge is influenced by… 
2012
2012
Development and validation of sensitive sandwich ELISAs for two investigational nonapeptide metastin receptor agonists, TAK-448 and TAK-683.
2010
2010
251 Potent and efficient testosterone suppression by chronic administration of novel metastin analogues, TAK-448 and TAK-683, in male rats
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