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Neurokinin B and Dynorphin A in Kisspeptin Neurons of the Arcuate Nucleus Participate in Generation of Periodic Oscillation of Neural Activity Driving Pulsatile Gonadotropin-Releasing Hormone
TLDR
Investigating the possible coexpression of kisspeptin, neurokinin B (NKB), and dynorphin A (Dyn) in neurons of the ARC of the goat and evaluating their potential roles in generating GnRH pulses found that all three neuropeptides are coexpressed in the same population of neurons. Expand
Follicular growth and atresia in mammalian ovaries: regulation by survival and death of granulosa cells.
TLDR
The factors that govern follicular growth and atresia, with a special focus on their regulation by granulosa cells, are discussed, in which hormones, growth factors and cytokines, death ligand-receptor system and B cell lymphoma/leukemia 2 (BCL2) family members are further discussed. Expand
Formation of olfactory memories mediated by nitric oxide
TLDR
Nitric oxide seems to act as a retrograde and/or intracellular messenger, being released from both mitral and granule cells to potentiate glutamate release from mitral cells by modulating cGMP contentrations. Expand
Neural Control of Maternal Behaviour and Olfactory Recognition of Offspring
TLDR
This review summarises a series of neuroanatomical, electrophysiological, in vivo sampling and behavioural neuropharmacological experiments carried out in sheep that have attempted to define the neural circuitry and hormonal neurotransmitter systems involved both in the control of maternal behaviour per se and in the selective olfactory recognition of lambs, which is the basis of an exclusive emotional bond between mother and offspring. Expand
Activation of Neuropeptide FF Receptors by Kisspeptin Receptor Ligands.
TLDR
The possible localization of secondary kisspeptin targets was demonstrated by variation in the levels of GnRH release from the median eminence and the type of GPR54 agonists used, which indicates the unidirectional cross-reactivity between both ligands. Expand
Neurobiological mechanisms underlying GnRH pulse generation by the hypothalamus
TLDR
The present article provides a brief historical background to the work that led to the concept of the GnRH pulse generator, and proposes that kisspeptin neurons in the arcuate nucleus are key players in this regard. Expand
Physiology of Reproduction
TLDR
In order to observe sexual behavior in rats, a male rat that has already been trained to mate with normal females several times is placed in a test cage under a red dim light and a steroid-induced estrous female is introduced. Expand
Kisspeptin and GnRH pulse generation.
TLDR
Analysis of hypothalamic multiple-unit activity revealed that KNDy neurons located in the hypothalamic arcuate nucleus might play a central role in the generation of GnRH pulses in goats, and perhaps other mammalian species. Expand
Molecular Characterization and Estrogen Regulation of Hypothalamic KISS1 Gene in the Pig1
TLDR
It is suggested that the PeN kisspeptin neurons could be responsible for the estrogen positive feedback regulation to induce gonadotropin-releasing hormone/luteinizing hormone (GnRH/LH) surge in the pig. Expand
Physiological role of metastin/kisspeptin in regulating gonadotropin-releasing hormone (GnRH) secretion in female rats
TLDR
The lactating rat model provided further evidence indicating that ARC metastin/kisspeptin neurons are involved in GnRH pulse generation, because pulsatile release of luteinizing hormone (LH) is profoundly suppressed by suckling stimulus and the LH pulse suppression is well associated with the suppression of ARC metastIn/ Kisspeptin and KiSS-1 gene expression in lactating rats. Expand
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