TAK-632

 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

BenzothiazolesNitriles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Computational study on the unbinding pathways of B-RAF inhibitors and its implication for the difference of residence time: insight from random acceleration and steered molecular dynamics simulations…
B-RAF kinase is a clinically validated target implicated in melanoma and advanced renal cell carcinoma (RCC). PLX4720 and TAK-632… (More)
  • table 2
Is this relevant?
2014
2014
Abstract 4247: Characterization of the selective pan-RAF inhibitor TAK-632 with antitumor activity in BRAF inhibitor-resistant melanoma
 
Is this relevant?
2013
2013
Antitumor activity of the selective pan-RAF inhibitor TAK-632 in BRAF inhibitor-resistant melanoma.
The mitogen-activated protein kinase (MAPK) pathway is particularly important for the survival and proliferation of melanoma… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 4
  • table 2
Is this relevant?
2013
2013
Discovery of a selective kinase inhibitor (TAK-632) targeting pan-RAF inhibition: design, synthesis, and biological evaluation of C-7-substituted 1,3-benzothiazole derivatives.
With the aim of discovering a selective kinase inhibitor targeting pan-RAF kinase inhibition, we designed novel 1,3-benzothiazole… (More)
Is this relevant?
2013
2013
Abstract C255: Discovery of TAK-632: A selective kinase inhibitor of pan-RAF with potent antitumor activity against BRAF and NRAS mutant melanomas.
 
Is this relevant?