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TAK-632

National Institutes of Health

Papers overview

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2019
2019
Necroptosis is a form of programmed, caspase‐independent, cell death, mediated by receptor‐interacting protein kinases, RIPK1 and… 
2019
2019
Necroptosis, a form of programmed cell death, plays a critical role in various diseases, including inflammatory, infectious, and… 
2019
2019
Biosynthesis of the pyrimidine nucleotide uridine monophosphate (UMP) is essential for cell proliferation and is achieved by the… 
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2016
2016
B-RAF kinase is a clinically validated target implicated in melanoma and advanced renal cell carcinoma (RCC). PLX4720 and TAK-632… 
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2016
2016
B-Raf(V600E) was an effective target for the treatment of human cancers. Based on a pan-Raf inhibitor TAK-632, a series of N-(4… 
2014
2014
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Melanoma is one of the deadliest and most aggressive forms… 
Highly Cited
2013
Highly Cited
2013
With the aim of discovering a selective kinase inhibitor targeting pan-RAF kinase inhibition, we designed novel 1,3-benzothiazole… 
Highly Cited
2013
Highly Cited
2013
The mitogen-activated protein kinase (MAPK) pathway is particularly important for the survival and proliferation of melanoma… 
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