TAK-632
National Institutes of Health
Papers overview
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Necroptosis is a form of programmed, caspase‐independent, cell death, mediated by receptor‐interacting protein kinases, RIPK1 and…
Necroptosis, a form of programmed cell death, plays a critical role in various diseases, including inflammatory, infectious, and…
B-RAF kinase is a clinically validated target implicated in melanoma and advanced renal cell carcinoma (RCC). PLX4720 and TAK-632…
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA
Melanoma is one of the deadliest and most aggressive forms…
With the aim of discovering a selective kinase inhibitor targeting pan-RAF kinase inhibition, we designed novel 1,3-benzothiazole…
The mitogen-activated protein kinase (MAPK) pathway is particularly important for the survival and proliferation of melanoma…