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TAK-375

National Institutes of Health

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ramelteon

Papers overview

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2011
2011
Efficient synthesis of [¹¹C]ramelteon as a positron emission tomography probe for imaging melatonin receptors involved in circadian rhythms.
Ramelteon (TAK-375) is a novel melatonin receptor agonist that is used for clinical treatment of insomnia. The present report… 
2009
2009
Molecular Cloning and Pharmacological Characterization of Monkey MT1 and MT2 Melatonin Receptors Showing High Affinity for the Agonist Ramelteon
Melatonin receptor agonists such as melatonin and ramelteon [(S)-N-[2-(1,6,7,8-tetrahydro-2H-indeno-[5,4-b]furan-8-yl)ethyl… 
2006
2006
Effect of ramelteon (TAK-375), a selective MT1/MT2 receptor agonist, on motor performance in mice
2006
2006
Introduction Insomnia is a major health concern as it is strongly associated with psychiatric , physical , social and economic morbidity
Efficacy: Published studies have demonstrated that ramelteon is safe and effective in the management of transient and chronic… 
2003
2003
TAK-375: Treatment of insomnia treatment of circadian rhythm disorders melatonin MT1/MT2 agonist
Melatonin is a neurohormone produced in the pineal gland that is involved in the regulation of circadian rhythm function. It… 
2002
2002
Kinetic resolution of an indan derivative using Bacillus sp. SUI-12: synthesis of a key intermediate of the melatonin receptor agonist TAK-375.
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