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TAK-063

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Pharmacological Phosphodiesterase Inhibition as a Therapeutic for Cortical and Striatal Stroke
Author(s): Abduljawad, Nora | Advisor(s): Carmichael, S. Thomas | Abstract: Stroke is the leading cause of adult disability, but… 
Review
2018
Review
2018
S225. A SYSTEMATIC REVIEW AND META-ANALYSIS OF PHARMACOLOGICAL INTERVENTIONS FOR REDUCTION OR PREVENTION OF WEIGHT GAIN IN SCHIZOPHRENIA
Abstract Background Weight gain is an extremely common problem in schizophrenia patients and is associated with morbidity and… 
Review
2018
Review
2018
S245. A Systematic Review and Meta-Analysis of Pharmacological Interventions for Reduction or Prevention of Weight Gain in Schizophrenia
2018
2018
S226. A STUDY COMPARING WEIGHT GAIN FROM ALKS 3831 TO OLANZAPINE IN EARLY-ILLNESS YOUNG ADULTS WITH SCHIZOPHRENIFORM, SCHIZOPHRENIA, OR BIPOLAR I DISORDER
Abstract Background Optimal pharmacological efficacy is crucial in first-episode and early-episode schizophrenia and bipolar I… 
2018
2018
S223. COMBINED TREATMENT WITH A SELECTIVE PDE10A INHIBITOR TAK-063 AND ANTIPSYCHOTICS AT SUBEFFECTIVE DOSES PRODUCES POTENT ANTIPSYCHOTIC-LIKE EFFECTS WITHOUT EXACERBATING SIDE EFFECTS PROFILE IN…
Abstract Background Activation of indirect pathway medium spiny neurons (MSNs) via promotion of cAMP production is the principal… 
2018
2018
S224. DELTA-9-TETRAHYDROCANNABINOL CHALLENGE IN CANNABIS USERS AND NON-USERS DIFFERENTIALLY AFFECTS BRAIN FUNCTION AND BEHAVIOR: AN FMRI STUDY OF DEVELOPMENT OF TOLERANCE
Abstract Background Cannabis use can induce acute and long-lasting psychosis and cognitive dysfunction. Some evidence suggests… 
2017
2017
The phosphodiesterase 10A selective inhibitor, TAK-063, induces c-Fos expression in both direct and indirect pathway medium spiny neurons and sub-regions of the medial prefrontal cortex in rats
2017
2017
Inhibitors of cGMP 3’,5’-Cyclic Phosphodiesterase 10A: A QSAR Study
A series of compounds with known experimental IC50 (nM) targeting phosphodiesterase10A (PDE10A) was studied. Recently PDE10A was… 
2017
2017
A strategy to improve the success rate of CNS drug development: TAK-063, a novel PDE10A inhibitor, as a case study.
  • H. Kimura
  • Nihon yakurigaku zasshi. Folia pharmacologica…
  • 2017
  • Corpus ID: 26354774
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