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T 440

Known as: T-440 
National Institutes of Health

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2 relations

Broader (2)

NaphthalenesPyridones

Papers overview

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2000
2000
An efficient synthesis of the anti-asthmatic agent T-440: a selective N-alkylation of 2-pyridone.
6,7-Diethoxy-1-[1-(2-methoxyethyl)-2-oxo-1,2-dihydropyridin- 4-yl]naphthalene-2,3-dimethanol [T-440, (1)] is a potential anti… 
1998
1998
A selective type 4 phosphodiesterase inhibitor, T-440, modulates intracellular cyclic AMP level and interleukin-2 production of Jurkat cells.
1997
1997
Effect of T-440, a novel type IV phosphodiesterase inhibitor, on allergen-induced immediate and late asthmatic reaction and leukocyte infiltration into the airways of guinea pigs.
Type IV phosphodiesterase (PDE IV) is expressed in many tissues including airway smooth muscle and inflammatory cells, suggesting… 
1997
1997
Prevention of ozone-induced airway hyperresponsiveness and epithelial injury by phosphodiesterase inhibitors in guinea pigs.
1997
1997
Late airway obstruction and neutrophil infiltration in sensitized mice after antigen provocation were suppressed by selective and non-selective phosphodiesterase inhibitors
ABSTRACT Suppression of antigen-induced late airway obstruction associated with neutrophilic inflammation by selective and non… 
1996
1996
A novel phosphodiesterase inhibitor, T-440: possible management of eosinophilic inflammation by down-regulation of interleukin-5 production.
The effect of T-440, a selective type IV phosphodiesterase (PDE IV) inhibitor on interleukin (IL)-5 production by peripheral… 
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