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T-3256336

National Institutes of Health

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2 relations

Broader (2)

OligopeptidesPyrazines

Papers overview

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2018
2018
Impact of P-Glycoprotein on Intestinal Absorption of an Inhibitor of Apoptosis Protein Antagonist in Rats: Mechanisms of Nonlinear Pharmacokinetics and Food Effects
PurposeThis study was designed to investigate the effects of P-glycoprotein (P-gp) expressed in the intestine on the nonlinear… 
2018
2018
Impact of P-Glycoprotein on Intestinal Absorption of an Inhibitor of Apoptosis Protein Antagonist in Rats: Mechanisms of Nonlinear Pharmacokinetics and Food Effects
This study was designed to investigate the effects of P-glycoprotein (P-gp) expressed in the intestine on the nonlinear… 
2016
2016
An inhibitor of apoptosis protein antagonist T-3256336 potentiates the antitumor efficacy of the Nedd8-activating enzyme inhibitor pevonedistat (TAK-924/MLN4924).
2016
2016
T-3256336, a novel and orally available small molecule IAP antagonist, induced tumor cell death via induction of systemic TNF alpha production.
2015
2015
Screening and Characterization of Hydrate Forms of T-3256336, a Novel Inhibitor of Apoptosis (IAP) Protein Antagonist.
Different crystal packing of hydrates from anhydrate crystals leads to different physical properties, such as solubility and… 
2013
2013
Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability…
2012
2012
Antitumor Activity and Pharmacodynamic Biomarkers of a Novel and Orally Available Small-Molecule Antagonist of Inhibitor of Apoptosis Proteins
Inhibitor of apoptosis proteins (IAP), which are key regulators of apoptosis, are inhibited by second mitochondria-derived… 
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