Suppressor of Fused Homolog

Known as: SUFU, SUFUH 
Suppressor of fused homolog (484 aa, ~54 kDa) is encoded by the human SUFU gene. This protein plays a role in both the hedgehog pathway and… (More)
National Institutes of Health

Related topics

Related topics

11 relations
Cell NucleusCytoplasmGenes, RegulatorHedgehog Signaling Pathway
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking
Two intraflagellar transport (IFT) complexes, IFT-A and IFT-B, build and maintain primary cilia and are required for activity of… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2011
2011
Modulation of the transactivation function and stability of Krüppel-like zinc finger protein Gli-similar 3 (Glis3) by Suppressor of Fused.
Glis3 is a member of the Glis subfamily of Krüppel-like zinc finger transcription factors. Recently, Glis3 has been linked to… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors.
Gli2 and Gli3 are primary transcriptional regulators that mediate hedgehog (Hh) signaling. Mechanisms that stabilize and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis.
Copper and iron are essential elements for cellular growth. Although bacteria have to overcome limitations of these metals by… (More)
Is this relevant?
2008
2008
SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of suppressor-of-fused in pancreatic cancer cell.
As a physically binding protein of GLI1 transcription factor, Suppressor-of-Fused (SUFU) has been placed in the center of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2008
2008
Novel Human Glioma-associated Oncogene 1 (GLI1) Splice Variants Reveal Distinct Mechanisms in the Terminal Transduction of the Hedgehog Signal*S⃞
Hedgehog (HH) signaling is one of the key pathways with major significance for embryogenesis, tumorigenesis, and stem cell… (More)
Is this relevant?
2008
2008
An intrinsic feed-forward mechanism for vertebrate gaze stabilization
transport; both proteins belong to the RND superfamily of proteins, originally defined by bacterial channel and transporter… (More)
  • figure 4
  • figure 1
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas.
BACKGROUND Basal cell carcinoma (BCC) of the skin is the most common human cancer. The genetic alterations underlying BCC… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Mutations in SUFU predispose to medulloblastoma
The sonic hedgehog (SHH) signaling pathway directs the embryonic development of diverse organisms and is disrupted in a variety… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Mammalian Suppressor-of-Fused modulates nuclear–cytoplasmic shuttling of GLI-1
Sonic hedgehog, Patched and Gli are components of a mammalian signalling pathway that has been conserved during evolution and… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?