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Suppressor of Fused Homolog

Known as: SUFU, SUFUH 
Suppressor of fused homolog (484 aa, ~54 kDa) is encoded by the human SUFU gene. This protein plays a role in both the hedgehog pathway and… Expand
National Institutes of Health

Related topics

Related topics

11 relations
Cell NucleusCytoplasmGenes, RegulatorHedgehog Signaling Pathway
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Papers overview

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Highly Cited
2012
Highly Cited
2012
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking
Mutations in mouse intraflagellar transport–A complex genes alter Sonic hedgehog signaling because of their effects on cilia… Expand
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Highly Cited
2010
Highly Cited
2010
Copper stress affects iron homeostasis by destabilizing iron-sulfur cluster formation in Bacillus subtilis.
Copper and iron are essential elements for cellular growth. Although bacteria have to overcome limitations of these metals by… Expand
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Highly Cited
2010
Highly Cited
2010
Suppressor of fused and Spop regulate the stability, processing and function of Gli2 and Gli3 full-length activators but not their repressors
Gli2 and Gli3 are primary transcriptional regulators that mediate hedgehog (Hh) signaling. Mechanisms that stabilize and… Expand
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Highly Cited
2009
Highly Cited
2009
Identification of a SUFU germline mutation in a family with Gorlin syndrome
Gorlin syndrome (GS) is inherited in an autosomal dominant pattern with high‐penetrance and is characterized by a range of… Expand
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Highly Cited
2006
Highly Cited
2006
Deregulation of the hedgehog signalling pathway: a possible role for the PTCH and SUFU genes in human rhabdomyoma and rhabdomyosarcoma development.
The naevoid basal cell carcinoma syndrome (NBCCS) is caused by mutations in the hedgehog receptor PTCH gene. It is characterized… Expand
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Highly Cited
2006
Highly Cited
2006
Comprehensive genomic analysis of desmoplastic medulloblastomas: identification of novel amplified genes and separate evaluation of the different histological components.
Desmoplastic medulloblastoma (DMB) is a malignant cerebellar tumour composed of two distinct tissue components, pale islands and… Expand
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Highly Cited
2005
Highly Cited
2005
Somatic mutations in the PTCH, SMOH, SUFUH and TP53 genes in sporadic basal cell carcinomas
Background  Basal cell carcinoma (BCC) of the skin is the most common human cancer. The genetic alterations underlying BCC… Expand
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Highly Cited
2003
Highly Cited
2003
Characterization of the Physical Interaction of Gli Proteins with SUFU Proteins*
The Hedgehog signaling pathway is involved in both development and cancer induction in a wide range of organisms. The end point… Expand
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Highly Cited
2002
Highly Cited
2002
Mutations in SUFU predispose to medulloblastoma
The sonic hedgehog (SHH) signaling pathway directs the embryonic development of diverse organisms and is disrupted in a variety… Expand
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Highly Cited
1999
Highly Cited
1999
Mammalian Suppressor-of-Fused modulates nuclear–cytoplasmic shuttling of GLI-1
Sonic hedgehog, Patched and Gli are components of a mammalian signalling pathway that has been conserved during evolution and… Expand
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