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Suppressor of Fused Homolog

Known as: SUFU, SUFUH 
Suppressor of fused homolog (484 aa, ~54 kDa) is encoded by the human SUFU gene. This protein plays a role in both the hedgehog pathway and… Expand
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Mutations in mouse intraflagellar transport–A complex genes alter Sonic hedgehog signaling because of their effects on cilia… Expand
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Highly Cited
2010
Highly Cited
2010
Copper and iron are essential elements for cellular growth. Although bacteria have to overcome limitations of these metals by… Expand
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Highly Cited
2010
Highly Cited
2010
Gli2 and Gli3 are primary transcriptional regulators that mediate hedgehog (Hh) signaling. Mechanisms that stabilize and… Expand
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Highly Cited
2009
Highly Cited
2009
Gorlin syndrome (GS) is inherited in an autosomal dominant pattern with high‐penetrance and is characterized by a range of… Expand
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Highly Cited
2006
Highly Cited
2006
The naevoid basal cell carcinoma syndrome (NBCCS) is caused by mutations in the hedgehog receptor PTCH gene. It is characterized… Expand
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Highly Cited
2006
Highly Cited
2006
Desmoplastic medulloblastoma (DMB) is a malignant cerebellar tumour composed of two distinct tissue components, pale islands and… Expand
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Highly Cited
2005
Highly Cited
2005
Background  Basal cell carcinoma (BCC) of the skin is the most common human cancer. The genetic alterations underlying BCC… Expand
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Highly Cited
2003
Highly Cited
2003
The Hedgehog signaling pathway is involved in both development and cancer induction in a wide range of organisms. The end point… Expand
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Highly Cited
2002
Highly Cited
2002
The sonic hedgehog (SHH) signaling pathway directs the embryonic development of diverse organisms and is disrupted in a variety… Expand
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Highly Cited
1999
Highly Cited
1999
Sonic hedgehog, Patched and Gli are components of a mammalian signalling pathway that has been conserved during evolution and… Expand
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