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Suppressor of Cytokine Signaling 3 Protein

Known as: SOCS3 Protein, Protein, SOCS3, Suppressor of Cytokine Signaling 3 Protein [Chemical/Ingredient] 
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal… 
National Institutes of Health

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In BloodProcess of secretionagonistsantagonists & inhibitors

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SOCS3 protein, human

Papers overview

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2019
2019
Intrauterine Growth Restriction Modifies the Accumbal Dopaminergic Response to Palatable Food Intake
2018
2018
Cytokine Signaling Protein 3 Deficiency in Myeloid Cells Promotes Retinal Degeneration and Angiogenesis through Arginase-1 Up-Regulation in Experimental Autoimmune Uveoretinitis.
2017
2017
SOCS3 ablation in SF1 cells causes modest metabolic effects during pregnancy and lactation
Highly Cited
2014
Highly Cited
2014
A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and function in vitro and in vivo
Macrophages respond to their microenvironment and develop polarized functions critical for orchestrating appropriate inflammatory… 
Highly Cited
2012
Highly Cited
2012
Mesenchymal Stem/Stromal Cells Induce the Generation of Novel IL-10–Dependent Regulatory Dendritic Cells by SOCS3 Activation
Suppression of immune response by mesenchymal stem/stromal cells (MSCs) is well documented. However, their regulatory effects on… 
2012
2012
Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance
Aims/hypothesisInflammation in obesity increases the levels of the suppressor of cytokine signalling-3 (SOCS3) protein in adipose… 
2008
2008
Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma
The constitutive activation of signal transducer and activator of transcription 3 (STAT3) participates in carcinogenesis through… 
Highly Cited
2008
Highly Cited
2008
Prognostic relevance of SOCS3 hypermethylation in patients with glioblastoma multiforme
Alterations in the signal transduction pathways are key mechanisms in the pathogenesis of de novo glioblastoma multiforme (GBM… 
Highly Cited
2003
Highly Cited
2003
The N-terminal Truncated Isoform of SOCS3 Translated from an Alternative Initiation AUG Codon under Stress Conditions Is Stable Due to the Lack of a Major Ubiquitination Site, Lys-6*
The suppressor of cytokine signaling-3 (SOCS3/CIS-33/SSI-3) is an important negative regulator of cytokine signaling. Here, we… 
2002
2002
Investigation of mRNA ablation strategies in ES cells
Embryonic stem (ES) cells are continuous cell lines derived from the inner cell mass of early mouse embryos and are capable of… 
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