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Bright light therapy: improved sensitivity to its effects on rest-activity rhythms in Alzheimer patients by application of nonparametric methods.
- E. V. van Someren, D. Swaab, C. Colenda, W. Cohen, W. McCall, P. Rosenquist
- BiologyChronobiology international
It was demonstrated that the light-induced improvement in coupling of the rest-activity rhythm to the environmental zeitgeber of bright light is better detected using nonparametric procedures, which will improve the sensitivity to treatment effects in future studies.
Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial.
- R. F. Riemersma-van der Lek, D. Swaab, J. Twisk, E. Hol, W. Hoogendijk, E. V. Van Someren
- Psychology, MedicineJAMA
- 11 June 2008
Light has a modest benefit in improving some cognitive and noncognitive symptoms of dementia and is recommended only in combination with light to counteract the adverse effect of melatonin on mood.
The stress system in the human brain in depression and neurodegeneration
A sex difference in the human brain and its relation to transsexuality
This study is the first to show a female brain structure in genetically male transsexuals and supports the hypothesis that gender identity develops as a result of an interaction between the developing brain and sex hormones.
Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients
The stress system in depression and neurodegeneration: Focus on the human hypothalamus
Hypocretin (orexin) loss in Parkinson's disease.
The hypocretin-1 concentration in the prefrontal cortex was almost 40% lower in PD patients, while ventricular CSF levels were almost 25% reduced, and the total number of hypoc retin neurons was almost half compared to controls.
Male-to-female transsexuals have female neuron numbers in a limbic nucleus.
- F. Kruijver, J. Zhou, C. Pool, M. A. Hofman, L. Gooren, D. Swaab
- Biology, PsychologyThe Journal of clinical endocrinology and…
- 1 May 2000
The present findings of somatostatin neuronal sex differences in the BSTc and its sex reversal in the transsexual brain clearly support the paradigm that in transsexuals sexual differentiation of the brain and genitals may go into opposite directions and point to a neurobiological basis of gender identity disorder.
Circadian rest—activity rhythm disturbances in alzheimer's disease