Suicide Gene Therapy
National Institutes of Health
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Cancer is a devastating disease characterized by uncontrolled and aggressive cell growth. Suicide gene therapy (SGT) facilitating…
The use of enzyme/prodrug system has gained attention because it could help improve the efficacy and safety of conventional…
ABSTRACT Introduction: Cancer is considered the second leading cause of death worldwide despite the progress made in early…
The Escherichia coli cytosine deaminase (CD)/5‐fluorocytosine (5‐FC) approach emerges as a potential aid for suicide gene therapy…
Suicide gene therapy mediated by mesenchymal stem cells with their ability to engraft into tumors makes these therapeutic stem…
Suicide gene therapy (SGT) is a promising strategy for treating cancer. In this work, we show that thymidine phosphorylase (TP…
OBJECTIVE
Intratumoral administration of adenoviral vector encoding herpes simplex virus (HSV) thymidine kinase (TK) gene (Ad-TK…
Chimeric antigen receptors (CARs) are generated by fusing the antigen-binding motif of a monoclonal antibody (mAb) with the…