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Suicide Gene Therapy

National Institutes of Health

Papers overview

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2014
2014
Thymidine phosphorylase is both a therapeutic and a suicide gene in a murine model of mitochondrial neurogastrointestinal encephalomyopathy
Suicide gene therapy (SGT) is a promising strategy for treating cancer. In this work, we show that thymidine phosphorylase (TP… 
2014
2014
Safety and Efficacy of Suicide Gene Therapy with Adenosine Deaminase 5-Fluorocytosine Silmutaneously in in Vitro Cultures of Melanoma and Retinal Cell Lines
Local treatment as a treatment modality is gaining increased general acceptance over time. Novel drugs and methodologies of local… 
2013
2013
Evaluation of miR-122-regulated suicide gene therapy for hepatocellular carcinoma in an orthotopic mouse model.
OBJECTIVE Intratumoral administration of adenoviral vector encoding herpes simplex virus (HSV) thymidine kinase (TK) gene (Ad-TK… 
2013
2013
Long-term safety and survival outcomes after TK-expressing donor lymphocyte infusion (TK-DLI) in allogeneic hematopoietic stem cell transplantation (HSCT).
7007 Background: Suicide gene therapy (SGT) was firstly applied to allogeneic HSCT, addressing the need for modulation of graft… 
2012
2012
TK-Cells Safety and Efficacy in Allogeneic Hematopoietic Stem Cell Transplantation: Long-Term Clinical and Molecular Assessment in 128 Treated Patients.
Abstract 3061 Background and methods. Suicide gene therapy (SGT) applied to allogeneic hematopoietic stem cell transplantation… 
2011
2011
Optimizing the Enzyme/Prodrug Axis of Suicide Gene Therapy Using Protein Engineering Strategies
By Adam James Johnson, Ph.D. Washington State University December 2011 Chair: Margaret E. Black The unifying goal of cancer… 
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