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Suicide Gene Therapy

 
National Institutes of Health

Papers overview

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2019
2019
Cancer Suicide Gene Therapy with TK.007.
Cancer is a devastating disease characterized by uncontrolled and aggressive cell growth. Suicide gene therapy (SGT) facilitating… Expand
2017
2017
Prodrug encapsulated albumin nanoparticles as an alternative approach to manifest anti-proliferative effects of suicide gene therapy.
Conventional anticancer agents are associated with limited therapeutic efficacy and substantial nonspecific cytotoxicity. Thus… Expand
2015
2015
Redesigned Escherichia coli cytosine deaminase: a new facet of suicide gene therapy
The Escherichia coli cytosine deaminase (CD)/5‐fluorocytosine (5‐FC) approach emerges as a potential aid for suicide gene therapy… Expand
Highly Cited
2014
Highly Cited
2014
Complete regression of glioblastoma by mesenchymal stem cells mediated prodrug gene therapy simulating clinical therapeutic scenario
Suicide gene therapy mediated by mesenchymal stem cells with their ability to engraft into tumors makes these therapeutic stem… Expand
2014
2014
Thymidine phosphorylase is both a therapeutic and a suicide gene in a murine model of mitochondrial neurogastrointestinal encephalomyopathy
Suicide gene therapy (SGT) is a promising strategy for treating cancer. In this work, we show that thymidine phosphorylase (TP… Expand
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2014
2014
Suicide plus immune gene therapy prevents post-surgical local relapse and increases overall survival in an aggressive mouse melanoma setting.
In an aggressive B16-F10 murine melanoma model, we evaluated the effectiveness and antitumor mechanisms triggered by a surgery… Expand
2014
2014
Safety and Efficacy of Suicide Gene Therapy with Adenosine Deaminase 5-Fluorocytosine Silmutaneously in in Vitro Cultures of Melanoma and Retinal Cell Lines
Local treatment as a treatment modality is gaining increased general acceptance over time. Novel drugs and methodologies of local… Expand
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2013
2013
Evaluation of miR-122-regulated suicide gene therapy for hepatocellular carcinoma in an orthotopic mouse model.
OBJECTIVE Intratumoral administration of adenoviral vector encoding herpes simplex virus (HSV) thymidine kinase (TK) gene (Ad-TK… Expand
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2011
2011
Suicide Gene Therapy to Increase the Safety of Chimeric Antigen Receptor-Redirected T Lymphocytes
Chimeric antigen receptors (CARs) are generated by fusing the antigen-binding motif of a monoclonal antibody (mAb) with the… Expand
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Highly Cited
2003
Highly Cited
2003
Treatment of rat gliosarcoma brain tumors by HSV-based multigene therapy combined with radiosurgery.
Our laboratory has employed replication-defective herpes simplex virus type 1 gene transfer vectors for treatment of animal… Expand
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