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Succinimides

Known as: succinimide, Butanimides, Pyrrolidinediones 
A subclass of IMIDES with the general structure of pyrrolidinedione. They are prepared by the distillation of ammonium succinate. They are sweet… Expand
National Institutes of Health

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3,3,4,4-tetramethylsuccinimide3-benzyl-N-(methanesulfonyloxy)succinimide3-maleimidobenzoyl N-hydroxysuccinimide5-(6)-carboxyfluorescein diacetate succinimidyl ester
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In BloodSuccinatesagonistsantagonists & inhibitors
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Papers overview

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Highly Cited
2014
Highly Cited
2014
Mild method for succinimide hydrolysis on ADCs: impact on ADC potency, stability, exposure, and efficacy.
The stability of the connection between the antibody and the toxin can have a profound impact on ADC safety and efficacy. There… Expand
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Highly Cited
2012
Highly Cited
2012
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
The reactive thiol in cysteine is used for coupling maleimide linkers in the generation of antibody conjugates. To assess the… Expand
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Highly Cited
2009
Highly Cited
2009
Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody.
Despite technological advances, detection of deamidation in large proteins remains a challenge and the use of orthogonal methods… Expand
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Highly Cited
2003
Highly Cited
2003
Femtomolar detection of prostate-specific antigen: an immunoassay based on surface-enhanced Raman scattering and immunogold labels.
A novel reagent for low-level detection in immunoadsorbent assays is described. The reagent consists of gold nanoparticles… Expand
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Highly Cited
2001
Highly Cited
2001
Block of cloned human T-type calcium channels by succinimide antiepileptic drugs.
Inhibition of T-type Ca(2+) channels has been proposed to play a role in the therapeutic action of succinimide antiepileptic… Expand
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Highly Cited
2001
Highly Cited
2001
Identification of multiple sources of charge heterogeneity in a recombinant antibody.
Seven forms of a therapeutic recombinant antibody that binds to the her2/neu gene product were resolved by cation-exchange… Expand
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Highly Cited
1995
Highly Cited
1995
GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import
Mediated import of proteins into the nucleus involves multiple cytosolic factors, including the small GTPase Ran. Whether Ran… Expand
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Highly Cited
1989
Highly Cited
1989
Succinimide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins.
Nonenzymatic intramolecular reactions can result in the deamidation, isomerization, and racemization of protein and peptide… Expand
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Highly Cited
1987
Highly Cited
1987
Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.
Aspartyl and asparaginyl deamidation, isomerization, and racemization reactions have been studied in synthetic peptides to model… Expand
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Highly Cited
1987
Highly Cited
1987
Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins.
  • S. Clarke
  • International journal of peptide and protein…
  • 1987
    • Corpus ID: 21155185
One mechanism for the spontaneous degradation of polypeptides is the intramolecular attack of the peptide bond nitrogen on the… Expand
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