Succinimides

Known as: succinimide, Butanimides, Pyrrolidinediones 
A subclass of IMIDES with the general structure of pyrrolidinedione. They are prepared by the distillation of ammonium succinate. They are sweet… (More)
National Institutes of Health

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3,3,4,4-tetramethylsuccinimide3-maleimidobenzoyl N-hydroxysuccinimide5-(6)-carboxyfluorescein diacetate succinimidyl ester6-maleimidohexanoic acid N-hydroxysuccinimide ester
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In BloodSuccinatesagonistsantagonists & inhibitors
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Papers overview

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2014
2014
Mild method for succinimide hydrolysis on ADCs: impact on ADC potency, stability, exposure, and efficacy.
The stability of the connection between the antibody and the toxin can have a profound impact on ADC safety and efficacy. There… (More)
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Highly Cited
2012
Highly Cited
2012
Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates
The reactive thiol in cysteine is used for coupling maleimide linkers in the generation of antibody conjugates. To assess the… (More)
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2009
2009
Deamidation of asparagine residues: direct hydrolysis versus succinimide-mediated deamidation mechanisms.
Quantum chemical calculations are reported to provide new insights on plausible mechanisms leading to the deamidation of… (More)
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2009
2009
Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain.
We investigated the formation and stability of succinimide, an intermediate of deamidation events, in recombinant monoclonal… (More)
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Highly Cited
2001
Highly Cited
2001
Block of cloned human T-type calcium channels by succinimide antiepileptic drugs.
Inhibition of T-type Ca(2+) channels has been proposed to play a role in the therapeutic action of succinimide antiepileptic… (More)
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Highly Cited
1994
Highly Cited
1994
Intrathalamic rhythmicity studied in vitro: nominal T-current modulation causes robust antioscillatory effects.
Thalamocortical oscillations mediate both physiological and pathophysiological behaviors including sleep and generalized absence… (More)
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Highly Cited
1989
Highly Cited
1989
Succinimide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins.
Nonenzymatic intramolecular reactions can result in the deamidation, isomerization, and racemization of protein and peptide… (More)
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Highly Cited
1989
Highly Cited
1989
Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence
I have synthesized a novel derivative of carboxyfluorescein that is nonfluorescent, but can be converted to a fluorescent form by… (More)
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Highly Cited
1987
Highly Cited
1987
Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.
Aspartyl and asparaginyl deamidation, isomerization, and racemization reactions have been studied in synthetic peptides to model… (More)
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Highly Cited
1987
Highly Cited
1987
Propensity for spontaneous succinimide formation from aspartyl and asparaginyl residues in cellular proteins.
One mechanism for the spontaneous degradation of polypeptides is the intramolecular attack of the peptide bond nitrogen on the… (More)
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