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Succinimides

Known as: succinimide, Butanimides, Pyrrolidinediones 
A subclass of IMIDES with the general structure of pyrrolidinedione. They are prepared by the distillation of ammonium succinate. They are sweet… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
The stability of the connection between the antibody and the toxin can have a profound impact on ADC safety and efficacy. There… Expand
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Highly Cited
2012
Highly Cited
2012
The reactive thiol in cysteine is used for coupling maleimide linkers in the generation of antibody conjugates. To assess the… Expand
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Highly Cited
2009
Highly Cited
2009
Despite technological advances, detection of deamidation in large proteins remains a challenge and the use of orthogonal methods… Expand
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Highly Cited
2003
Highly Cited
2003
A novel reagent for low-level detection in immunoadsorbent assays is described. The reagent consists of gold nanoparticles… Expand
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Highly Cited
2001
Highly Cited
2001
Inhibition of T-type Ca(2+) channels has been proposed to play a role in the therapeutic action of succinimide antiepileptic… Expand
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Highly Cited
2001
Highly Cited
2001
Seven forms of a therapeutic recombinant antibody that binds to the her2/neu gene product were resolved by cation-exchange… Expand
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Highly Cited
1995
Highly Cited
1995
Mediated import of proteins into the nucleus involves multiple cytosolic factors, including the small GTPase Ran. Whether Ran… Expand
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Highly Cited
1989
Highly Cited
1989
Nonenzymatic intramolecular reactions can result in the deamidation, isomerization, and racemization of protein and peptide… Expand
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Highly Cited
1987
Highly Cited
1987
Aspartyl and asparaginyl deamidation, isomerization, and racemization reactions have been studied in synthetic peptides to model… Expand
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Highly Cited
1987
Highly Cited
1987
  • S. Clarke
  • International journal of peptide and protein…
  • 1987
  • Corpus ID: 21155185
One mechanism for the spontaneous degradation of polypeptides is the intramolecular attack of the peptide bond nitrogen on the… Expand
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