Succinimides

Known as: succinimide, Butanimides, Pyrrolidinediones 
A subclass of IMIDES with the general structure of pyrrolidinedione. They are prepared by the distillation of ammonium succinate. They are sweet… (More)
National Institutes of Health

Papers overview

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2014
2014
The stability of the connection between the antibody and the toxin can have a profound impact on ADC safety and efficacy. There… (More)
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Highly Cited
2012
Highly Cited
2012
The reactive thiol in cysteine is used for coupling maleimide linkers in the generation of antibody conjugates. To assess the… (More)
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2009
2009
Quantum chemical calculations are reported to provide new insights on plausible mechanisms leading to the deamidation of… (More)
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2009
2009
We investigated the formation and stability of succinimide, an intermediate of deamidation events, in recombinant monoclonal… (More)
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Highly Cited
2001
Highly Cited
2001
Inhibition of T-type Ca(2+) channels has been proposed to play a role in the therapeutic action of succinimide antiepileptic… (More)
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Highly Cited
1994
Highly Cited
1994
Thalamocortical oscillations mediate both physiological and pathophysiological behaviors including sleep and generalized absence… (More)
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Highly Cited
1989
Highly Cited
1989
Nonenzymatic intramolecular reactions can result in the deamidation, isomerization, and racemization of protein and peptide… (More)
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Highly Cited
1989
Highly Cited
1989
I have synthesized a novel derivative of carboxyfluorescein that is nonfluorescent, but can be converted to a fluorescent form by… (More)
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Highly Cited
1987
Highly Cited
1987
Aspartyl and asparaginyl deamidation, isomerization, and racemization reactions have been studied in synthetic peptides to model… (More)
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Highly Cited
1987
Highly Cited
1987
One mechanism for the spontaneous degradation of polypeptides is the intramolecular attack of the peptide bond nitrogen on the… (More)
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