Structure of beta Cell of islet
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Human induced pluripotent stem cells (HiPSCs) appear to be highly similar to human embryonic stem cells (HESCs). Using two… Expand The molecular mechanisms involved in the development of type 2 diabetes are poorly understood. Starting from genome-wide genotype… Expand Gut peptides, exemplified by glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are secreted… Expand Glucose in chronic excess causes toxic effects on structure and function of organs, including the pancreatic islet. Multiple… Expand To evaluate the role of oncogenic RAS mutations in pancreatic tumorigenesis, we directed endogenous expression of KRAS(G12D) to… Expand The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes have been… Expand Type 2 diabetes mellitus (DM) is characterized by insulin resistance and pancreatic β cell dysfunction. In high-risk subjects… Expand A major obstacle to successful islet transplantation for both type 1 and 2 diabetes is an inadequate supply of insulin-producing… Expand OBJECTIVE
The authors reviewed the pathology, complications, and outcomes in a consecutive group of 650 patients undergoing… Expand A member of the inwardly rectifying potassium channel family was cloned here. The channel, called BIR (Kir6.2), was expressed in… Expand