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Sterol O-Acyltransferase

Known as: Cholesterol Acyltransferase, Acyltransferase, Acyl-CoA-Cholesterol, Acyl-CoA:cholesterol O-acyltransferase 
An enzyme that catalyzes the formation of cholesterol esters by the direct transfer of the fatty acid group from a fatty acyl CoA derivative. This… 
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (3)

ARE1 protein, S cerevisiaesterol O-acyltransferase 1sterol O-acyltransferase 2
In BloodProcess of secretionSOAT1 geneantagonists & inhibitors

Papers overview

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Highly Cited
1997
Highly Cited
1997
Quantitation of the Pool of Cholesterol Associated with Acyl-CoA:Cholesterol Acyltransferase in Human Fibroblasts*
The esterification of cholesterol in homogenates of human fibroblasts was explored as a means of estimating the size of the pool… 
Highly Cited
1996
Highly Cited
1996
Sphingomyelin Inhibits the Lecithin-Cholesterol Acyltransferase Reaction with Reconstituted High Density Lipoproteins by Decreasing Enzyme Binding*
Lecithin-cholesterol acyltransferase (LCAT) catalyzes the formation of cholesterol esters on high density lipoproteins (HDL) and… 
Highly Cited
1995
Highly Cited
1995
Properties of an N-terminal proteolytic fragment of apolipoprotein AI in solution and in reconstituted high density lipoproteins
Limited proteolysis was used to study the domain structure and to produce a large N-terminal fragment of human apolipoprotein AI… 
Highly Cited
1993
Highly Cited
1993
Apolipoprotein A-I domains involved in lecithin-cholesterol acyltransferase activation. Structure:function relationships.
Highly Cited
1985
Highly Cited
1985
Preferential enrichment of large-sized very low density lipoprotein populations with transferred cholesteryl esters.
The effect of lipid transfer proteins on the exchange and transfer of cholesteryl esters from rat plasma HDL2 to human very low… 
Highly Cited
1984
Highly Cited
1984
Reduced cholesterol transmucosal transport in rats with inhibited mucosal acyl CoA:cholesterol acyltransferase and normal pancreatic function.
Absorption of cholesterol during inhibition of mucosal acyl CoA:cholesterol acyltransferase was studied in mesenteric lymph… 
Highly Cited
1983
Highly Cited
1983
Role of acyl CoA:cholesterol acyltransferase in cholesterol absorption and its inhibition by 57-118 in the rabbit.
Esterification of cholesterol in rabbit small intestine mucosal microsomes by acyl CoA:cholesterol acyltransferase (ACAT, Ec 2.3… 
Highly Cited
1983
Highly Cited
1983
An inherited polymorphism in the human apolipoprotein A-I gene locus related to the development of atherosclerosis
Epidemiological studies have identified elevated low density lipoprotein (LDL)1–3 and diminished high density lipoprotein (HDL… 
Highly Cited
1980
Highly Cited
1980
The mechanism of activation of lecithin:cholesterol acyltransferase by apolipoprotein A-I and an amphiphilic peptide.
A synthetic docosapeptide designed to have the op- timal amphiphilic a-helical potential was shown to bind with a simple Langmuir… 
Highly Cited
1978
Highly Cited
1978
Rat-liver acyl-CoA: cholesterol acyltransferase.
The activity of acyl-CoA:cholesterol acyltransferase was measured in rat-liver microsomes from the rate of incorporation of [1… 
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