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Squalene monooxygenase
Known as:
Squalene Monooxygenase (2,3-Epoxidizing)
, Squalene Epoxidase
, Epoxidase, Squalene
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The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of…
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National Institutes of Health
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Related topics
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8 relations
In Blood
Process of secretion
SQLE gene
antagonists & inhibitors
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Photoaffinity labeling identifies the substrate-binding site of mammalian squalene epoxidase.
H. Lee
,
Y. Zheng
,
+4 authors
G. Prestwich
Biochemical and Biophysical Research…
2004
Corpus ID: 19253760
2003
2003
Mechanistic insights into oxidosqualene cyclizations through homology modeling
T. Schulz-Gasch
,
M. Stahl
Journal of Computational Chemistry
2003
Corpus ID: 16216022
2,3‐Oxidosqualene cyclases (OSC) are key enzymes in sterol biosynthesis. They catalyze the stereoselective cyclization and…
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2003
2003
Phosphorylation of Supernatant Protein Factor Enhances Its Ability to Stimulate Microsomal Squalene Monooxygenase*
Dev K. Singh
,
V. Mokashi
,
C. L. Elmore
,
T. Porter
Journal of Biological Chemistry
2003
Corpus ID: 37522215
Supernatant protein factor is a 46-kDa cytosolic protein that stimulates squalene monooxygenase, a downstream enzyme in the…
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2000
2000
Inhibitors of Sterol Biosynthesis and Amphotericin B Reduce the Viability of Pneumocystis carinii f. sp.carinii
E. Kaneshiro
,
M. Collins
,
M. Cushion
Antimicrobial Agents and Chemotherapy
2000
Corpus ID: 21155610
ABSTRACT Pneumocystis carinii synthesizes sterols with a double bond at C-7 of the sterol nucleus and an alkyl group with one or…
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2000
2000
Photoaffinity labeling and site-directed mutagenesis of rat squalene epoxidase.
H. K. Lee
,
P. Denner-Ancona
,
J. Sakakibara
,
T. Ono
,
G. Prestwich
Archives of Biochemistry and Biophysics
2000
Corpus ID: 23283742
Squalene epoxidase (SE) (EC 1.14.99.7) is a flavin-requiring, non-cytochrome P-450 oxidase that catalyzes the conversion of…
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1999
1999
Amidrazone and Amidoxime Inhibitors of Squalene Hopene Cyclase.
B. Ganem
,
Yaohua Dong
,
Y. Zheng
,
G. Prestwich
Journal of Organic Chemistry
1999
Corpus ID: 10518078
The cyclization of squalene catalyzed by the enzyme squalene-hopene cyclase (SHC) leads to the hopanoid family of pentacyclic…
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1992
1992
Preferential cyclization of 2,3(S):22(S),23-dioxidosqualene by mammalian 2,3-oxidosqualene-lanosterol cyclase.
O. Boutaud
,
D. Dolis
,
F. Schuber
Biochemical and Biophysical Research…
1992
Corpus ID: 31694432
1982
1982
Purification and partial characterization of squalene epoxidase from rat liver microsomes.
T. Ono
,
K. Nakazono
,
H. Kosaka
Biochimica et Biophysica Acta
1982
Corpus ID: 19514202
1980
1980
Purification of squalene epoxidase from rat liver microsomes.
T. Ono
,
K. Takahashi
,
S. Odani
,
H. Konno
,
Y. Imai
Biochemical and Biophysical Research…
1980
Corpus ID: 10153091
1957
1957
Squalene Content of Various Shark Livers
J. Heller
,
M. S. Heller
,
S. Springer
,
E. Clark
Nature
1957
Corpus ID: 4280803
SINCE the demonstration that squalene might be an important precursor to cholesterol in endogenous synthesis1–3, it was felt that…
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