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Sporadic Breast Carcinoma

Known as: Sporadic Breast Cancer 
A carcinoma that arises from the breast and is not caused by inherited genetic mutations.
National Institutes of Health

Related topics

Related topics

21 relations
BreastChromosome 13q deletionEpithelial CellsEpithelium

Papers overview

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Highly Cited
2011
Highly Cited
2011
MTHFR polymorphisms and breast cancer risk
Introduction Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene… 
Highly Cited
2008
Highly Cited
2008
MDM2 SNP309 G allele increases risk but the T allele is associated with earlier onset age of sporadic breast cancers in the Chinese population.
Sporadic breast cancer in women <40 years is uncommon in Caucasians, in contrast to a much earlier onset in Chinese Asians… 
Highly Cited
2007
Highly Cited
2007
Implication of BRCA2 -26G>A 5' untranslated region polymorphism in susceptibility to sporadic breast cancer and its modulation by p53 codon 72 Arg>Pro polymorphism
IntroductionThe absence of mutation or promoter hypermethylation in the BRCA2 gene in the majority of breast cancer cases has… 
Highly Cited
2004
Highly Cited
2004
Surfaced-Enhanced Laser Desorption/Ionization Time-of-Flight (SELDI-TOF) Differentiation of Serum Protein Profiles of BRCA-1 and Sporadic Breast Cancer
AbstractBackground: BRCA-1 mutations predispose women to early onset breast cancer, but ∼20% never develop cancer. Surface… 
Highly Cited
2001
Highly Cited
2001
Quantification of estrogen receptor alpha and beta expression in sporadic breast cancer.
The recent cloning of a second estrogen receptor (ER), designated ERbeta, has prompted a reevaluation of the role of ERs in… 
Highly Cited
2000
Highly Cited
2000
Elevated frequency and functional activity of a specific germ-line p53 intron mutation in familial breast cancer.
Previous studies have determined that the frequency of germ-line p53 mutations in familial breast cancer patients is 1% or less… 
Highly Cited
1999
Highly Cited
1999
The Brn-3b POU family transcription factor represses expression of the BRCA-1 anti-oncogene in breast cancer cells
The BRCA-1 tumour supressor gene was identified on the basis of mutations which occur in familial breast cancer indicating that… 
Highly Cited
1999
Highly Cited
1999
Immunolocalization of BRCA1 protein in normal breast tissue and sporadic invasive ductal carcinomas: a correlation with other biological parameters
BRCA1, a nuclear phosphoprotein, normally functions as a negative regulator of the cell cycle and may be an active inhibitor of… 
Highly Cited
1998
Highly Cited
1998
Down-regulation of BRCA1 in human sporadic breast cancer; analysis of DNA methylation patterns of the putative promoter region
Germ-line alterations of BRCA1 are responsible for about 50% of familial breast cancers. Although its biological function(s) has… 
Highly Cited
1997
Highly Cited
1997
Patterns of allelic loss on chromosome 17 in sporadic breast carcinomas detected by fluorescent‐labeled microsatellite analysis
Loss of heterozygosity (LOH) on chromosome 17 is a frequent genetic alteration in breast cancer. To assess whether the location… 
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