Spliceosome Assembly Pathway

Known as: Spliceosome Assembly 
The assembly of the spliceosome is a dynamic process that involves both small ribonucleoprotein particles (snRNPs), and non-snRNP proteins. The… (More)
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton ribonucleoprotein (RNP) complex comprised of five snRNPs and… (More)
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2008
2008
The spliceosome uses numerous strategies to regulate its function in mRNA maturation. Ubiquitin regulates many cellular processes… (More)
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Highly Cited
2005
Highly Cited
2005
Coupling between transcription and pre-mRNA splicing is a key regulatory mechanism in gene expression. Here, we investigate… (More)
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Highly Cited
2005
Highly Cited
2005
To investigate the mechanism of spliceosome assembly in vivo, we performed chromatin immunoprecipitation (ChIP) analysis of U1… (More)
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Highly Cited
1994
Highly Cited
1994
Splicing of mRNA precursors (pre-mRNA) is preceded by assembly of the pre-mRNA with small nuclear ribonucleoprotein particles… (More)
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1992
1992
A mammalian splicing commitment complex was functionally defined by using a template commitment assay. This complex was partially… (More)
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Highly Cited
1991
Highly Cited
1991
Previous studies have identified five distinct mammalian splicing complexes that assemble on pre-mRNA in vitro. Of these… (More)
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Highly Cited
1990
Highly Cited
1990
A monoclonal antibody raised against mammalian spliceosomes specifically recognizes a non-snRNP factor required for spliceosome… (More)
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Highly Cited
1989
Highly Cited
1989
Although both U1 and U2 snRNPs have been implicated in the splicing process, their respective roles in the earliest stages of… (More)
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Highly Cited
1987
Highly Cited
1987
Precursors to mRNA become substrates for splicing by being assembled into a complex multisubunit structure, the spliceosome. To… (More)
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