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Spliceosome Assembly Pathway

Known as: Spliceosome Assembly 
The assembly of the spliceosome is a dynamic process that involves both small ribonucleoprotein particles (snRNPs), and non-snRNP proteins. The… 
National Institutes of Health

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Related topics

6 relations
SNRPF wt AlleleSRSF2 wt AlleleSerine/Arginine-Rich Splicing Factor 2Small Nuclear Ribonucleoprotein Polypeptide F

Papers overview

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Highly Cited
1997
Highly Cited
1997
A novel mechanism of aberrant pre-mRNA splicing in humans.
Eukaryotic pre-mRNA splicing is regulated by consensus sequences at the intron boundaries and branch site. Recently, Sirand… 
Highly Cited
1996
Highly Cited
1996
CUS1, a suppressor of cold-sensitive U2 snRNA mutations, is a novel yeast splicing factor homologous to human SAP 145.
The function of U2 snRNA in splicing is mediated by the proteins of the U2 small nuclear ribonucleoprotein. To identify proteins… 
Highly Cited
1994
Highly Cited
1994
Direct interactions between pre-mRNA and six U2 small nuclear ribonucleoproteins during spliceosome assembly
Highly purified mammalian spliceosomal complex B contains more than 30 specific protein components. We have carried out UV cross… 
Highly Cited
1994
Highly Cited
1994
U4/U5/U6 snRNP recognizes the 5' splice site in the absence of U2 snRNP.
Using an in vitro system in which a 5' splice site (5'SS) RNA oligo (AAG decreases GUAAGUAdT) is capable of inducing formation of… 
Highly Cited
1993
Highly Cited
1993
Disruption of base pairing between the 5′ splice site and the 5′ end of U1 snRNA is required for spliceosome assembly
Highly Cited
1993
Highly Cited
1993
Mutation of an RSV intronic element abolishes both U11/U12 snRNP binding and negative regulation of splicing.
A cis-acting negative regulator of splicing (NRS) within the gag gene of RSV is involved in control of the relative levels of… 
Highly Cited
1991
Highly Cited
1991
Alpha-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice.
We have used exons 2 and 3 of the rat alpha-tropomyosin gene to analyze the basis of mutually exclusive exon selection. The basis… 
Highly Cited
1991
Highly Cited
1991
Efficient association of U2 snRNPs with pre-mRNA requires an essential U2 RNA structural element.
To understand the role of U2 RNA structure in pre-mRNA splicing we have characterized several cold-sensitive mutations in an… 
1991
1991
Biotinylated antisense methylphosphonate oligodeoxynucleotides. Inhibition of spliceosome assembly and affinity selection of U1 and U2 small nuclear RNPs.
Highly Cited
1989
Highly Cited
1989
Mammalian U2 snRNP has a sequence-specific RNA-binding activity.
The RNA branch formed during pre-mRNA splicing occurs at a wide variety of sequences (branch sites) in different mammalian pre… 
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