Skip to search formSkip to main contentSkip to account menu

Sphingomyelin Phosphodiesterase 3

Known as: SMPD3, nSMase2, Neutral Sphingomyelinase II 
Sphingomyelin phosphodiesterase 3 (655 aa, ~71 kDa) is encoded by the human SMPD3 gene. This protein plays a role in ceramide biosynthesis.
National Institutes of Health

Related topics

Related topics

8 relations
Ceramide Signaling Pathway PIDEnzyme GeneEsterase GeneHydrolase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Neutral sphingomyelinase (SMPD3) deficiency disrupts the Golgi secretory pathway and causes growth inhibition
Systemic loss of neutral sphingomyelinase (SMPD3) in mice leads to a novel form of systemic, juvenile hypoplasia (dwarfism… 
2014
2014
Ceramide mediates acute oxygen sensing in vascular tissues.
AIMS A variety of vessels, such as resistance pulmonary arteries (PA) and fetoplacental arteries and the ductus arteriosus (DA… 
2014
2014
Secretion of small/microRNAs including miR-638 into extracellular spaces by sphingomyelin phosphodiesterase 3
A recent study demonstrated that intracellular small/microRNAs are released from cells, and some of these extracellular RNAs are… 
Highly Cited
2013
Highly Cited
2013
Genome-wide methylation analysis and epigenetic unmasking identify tumor suppressor genes in hepatocellular carcinoma.
BACKGROUND & AIMS Epigenetic silencing of tumor suppressor genes contributes to the pathogenesis of hepatocellular carcinoma (HCC… 
2013
2013
Local Regulation of Tooth Mineralization by Sphingomyelin Phosphodiesterase 3
Sphingomyelin phosphodiesterase 3 (Smpd3) encodes a membrane-bound enzyme that cleaves sphingomyelin to generate several… 
Highly Cited
2011
Highly Cited
2011
Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury.
Chronic obstructive pulmonary disease (COPD) is caused by exposure to cigarette smoke (CS). One mechanism of CS-induced lung… 
2010
2010
Expression and regulation of enzymes in the ceramide metabolic pathway in human retinal pigment epithelial cells and their relevance to retinal degeneration
2009
2009
Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin.
2009
2009
Upregulation of smpd3 via BMP2 stimulation and Runx2.
Deletion of smpd3 induces osteogenesis and dentinogenesis imperfecta in mice. smpd3 is highly elevated in the parietal bones of… 
Highly Cited
2005
Highly Cited
2005
A deletion in the gene encoding sphingomyelin phosphodiesterase 3 (Smpd3) results in osteogenesis and dentinogenesis imperfecta in the mouse
The mouse mutation fragilitas ossium (fro) leads to a syndrome of severe osteogenesis and dentinogenesis imperfecta with no… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)