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Sphingomyelin Phosphodiesterase 3

Known as: SMPD3, nSMase2, Neutral Sphingomyelinase II 
Sphingomyelin phosphodiesterase 3 (655 aa, ~71 kDa) is encoded by the human SMPD3 gene. This protein plays a role in ceramide biosynthesis.
National Institutes of Health

Related topics

Related topics

8 relations
Ceramide Signaling Pathway PIDEnzyme GeneEsterase GeneHydrolase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Neutral Sphingomyelinase 2 (SMPD3)-Deficiency in Mice Causes Chondrodysplasia with Unimpaired Skeletal Mineralization.
2019
2019
Abstract C20: Smpd3 augments chemotherapy and thwarts PDA progression
Deregulated sphingolipid metabolism alters pancreatic cancer progression; for that reason, bioactive lipid signaling molecules… 
2018
2018
SMPD3 deficiency perturbs neuronal proteostasis and causes progressive cognitive impairment
Neutral sphingomyelinase smpd3 is most abundantly expressed in neurons of brain. The function of SMPD3 has remained elusive. Here… 
2016
2016
Effects of SMPD3 on cytodifferentiation of periodontal ligament cells
2016
2016
[Effect of jianpi-jiedu formula on tumor angiogenesis-relevant genes expression in colorectal cancer].
OBJECTIVE To investigate the effect of the jianpi-jiedu formula (JPJD) on the expression of angiogenesis-relevant genes in colon… 
2013
2013
192 MODULATED EXOSOME SECRETION BY VASCULAR SMOOTH MUSCLE CELLS IS A NOVEL REGULATORY MECHANISM OF VASCULAR CALCIFICATION
Vascular calcification is a regulated pathological process similar to bone formation which is mediated by vascular smooth muscle… 
2012
2012
Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue
Inflammation and increased ceramide concentrations characterise adipose tissue of obese women with high liver fat content… 
2011
2011
Lack Of The Neutral Sphingomyelinase NSMASE2 Induces Lung Dysfunction Similar To Emphysema
2009
2009
Upregulation of smpd 3 via BMP 2 stimulation and Runx 2
Deletion of smpd3 induces osteogenesis and dentinogenesis imperfecta in mice. smpd3 is highly elevated in the parietal bones of… 
1988
1988
MAGNETIC PROPERTIES OF THE AuCu3-TYPE Sm-COMPOUNDS
Resistivity, susceptibility, specific heat and magnetization measurements on single crystals SmPb3, SmPd3 and SmTl3 are performed… 
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