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Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement.
TLDR
Platelet-released sphingosine 1-phosphate, linked to Rac- and Rho-dependent cytoskeletal rearrangement, may act late in angiogenesis to stabilize newly formed vessels, which often display abnormally increased vascular permeability. Expand
Myosin light chain kinase in endothelium: molecular cloning and regulation.
TLDR
The cloning and expression of a nonmuscle MLCK isoform in cultured endothelium is reported and potentially novel mechanisms of endothelial cell contraction and barrier regulation are suggested. Expand
Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: Role of Rho‐dependent mechanisms
TLDR
This study investigated the crosstalk between MT and actomyosin cytoskeleton and characterized specific molecular mechanisms of endothelial cells (EC) barrier dysfunction induced by MT inhibitor nocodazole, and suggests Rho‐kinase and MYPT1 as major Rho effectors mediating pulmonary EC barrier disruption in response to ND‐induced MT disassembly. Expand
Differential Regulation of Alternatively Spliced Endothelial Cell Myosin Light Chain Kinase Isoforms by p60Src *
TLDR
Results demonstrate for the first time that p60Src-mediated tyrosine phosphorylation represents an important mechanism for splice variant-specific regulation of nonmuscle MLCK and vascular cell function. Expand
Arachidonic acid cascade in endothelial pathobiology.
TLDR
Endothelial-specific synthesis and action of arachidonic acid derivatives with a particular focus on the mechanisms of signal transduction and associated intracellular protein targets are discussed. Expand
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction.
TLDR
It is demonstrated that thrombin-induced decreases in transendothelial electrical resistance (TER) indicating EC barrier dysfunction are universal for human and bovine pulmonary endothelium, and involve membrane translocation and direct activation of small GTPase Rho and its downstream target Rho-kinase and guanosine nucleotide exchange factor p115-RhoGEF. Expand
Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunction.
TLDR
A central role for the endothelial cell cytoskeleton is indicated in TNF-alpha-mediated apoptosis, whereas TNF -alpha-induced vascular permeability appears to evolve independently of contractile tension generation. Expand
Microtubule disassembly increases endothelial cell barrier dysfunction: role of MLC phosphorylation.
TLDR
Results suggest that microtubule disruption initiates specific signaling pathways that cross talk with microfilament networks, resulting in Rho-mediated EC contractility and barrier dysfunction. Expand
GEF-H1 is involved in agonist-induced human pulmonary endothelial barrier dysfunction.
TLDR
A critical role is shown for the GEF-H1 in the Rho activation caused by MT disassembly and GEF/GTP exchange factor is suggested as a key molecule involved in cross talk between MT and actin cytoskeleton in agonist-induced Rho-dependent EC barrier regulation. Expand
Molecular Mechanisms of Thrombin-Induced Endothelial Cell Permeability
TLDR
Thrombin-induced rearrangement in the endothelial cytoskeleton is regulated by Ca2+/calmodulin-dependentprotein kinase, protein kinase C, and tyrosine protein kinases. Expand
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