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Solute Carrier Family 12, Member 1

Known as: Protein, SLC12A1, SLC12A1 Cotransporter, BSC1 Transport Protein 
Na-K-Cl transporter in the ASCENDING LIMB OF LOOP OF HENLE. It mediates active reabsorption of sodium chloride and is inhibited by LOOP DIURETICS… Expand
National Institutes of Health

Related topics

Related topics

13 relations
Bartter DiseaseIn BloodProcess of secretionSLC12A1 gene
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Narrower (2)

Bartter syndrome, antenatal type 1SLC12A1 protein, human

Papers overview

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2019
2019
Hepsin-mediated Processing of Uromodulin is Crucial for Salt-sensitivity and Thick Ascending Limb Homeostasis
Uromodulin is a zona pellucida-type protein essentially produced in the thick ascending limb (TAL) of the mammalian kidney. It is… Expand
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2016
2016
A missense mutation in solute carrier family 12, member 1 (SLC12A1) causes hydrallantois in Japanese Black cattle
BackgroundHydrallantois is the excessive accumulation of fluid within the allantoic cavity in pregnant animals and is associated… Expand
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2014
2014
Na+/K+-ATPase β1-subunit is recruited in Na-K-2Cl co-transporter isoform 2 multiprotein complexes in rat kidneys: possible role in blood pressure regulation.
OBJECTIVE The progression from prehypertensive to hypertensive state in spontaneous hypertensive rats (SHRs) is accompanied by a… Expand
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2013
2013
Adenylyl cyclase 6 enhances NKCC2 expression and mediates vasopressin-induced phosphorylation of NKCC2 and NCC.
Arginine vasopressin (AVP) affects kidney function via vasopressin V2 receptors that are linked to activation of adenylyl cyclase… Expand
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2012
2012
Multiple evolutionarily conserved Di-leucine like motifs in the carboxyl terminus control the anterograde trafficking of NKCC2.
Mutations in the apical Na-K-2Cl co-transporter, NKCC2, cause type I Bartter syndrome, a life-threatening kidney disease. Yet the… Expand
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2011
2011
Rare mutations in SLC12A1 and SLC12A3 protect against hypertension by reducing the activity of renal salt cotransporters.
OBJECTIVES Screening for variants in SLC12A1 and SLC12A3 genes, encoding the renal Na:Cl (NCC) and Na:K:2Cl (NKCC2… Expand
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2011
2011
Gene expression profiling in ethnic Malays with type 2 diabetes mellitus, with and without diabetic nephropathy.
BACKGROUND Diabetic nephropathy (DN) is the most common cause of end-stage renal disease (ESRD) among type 2 diabetes mellitus… Expand
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2004
2004
Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease.
Most of the missense mutations that have been described in the human SLC12A3 gene encoding the thiazide-sensitive Na(+)-Cl… Expand
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1997
1997
Mutations in the gene encoding the inwardly-rectifying renal potassium channel, ROMK, cause the antenatal variant of Bartter syndrome: evidence for genetic heterogeneity. International Collaborative…
Inherited renal tubular disorders associated with hypokalemic alkalosis (Bartter-like syndromes) can be subdivided into at least… Expand
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1968
1968
Adsorption, penetration and uncoating of herpes simplex virus.
Summary The interaction of herpes virus particles with BSC1 cells was studied with purified virus particles labelled in the DNA… Expand
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