Skip to search formSkip to main contentSkip to account menu

SLC12A1 gene

Known as: SODIUM-POTASSIUM-CHLORIDE TRANSPORTER 2, solute carrier family 12 member 1, SLC12A1 
National Institutes of Health

Related topics

Related topics

1 relation
Solute Carrier Family 12, Member 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
SPAK differentially mediates vasopressin effects on sodium cotransporters.
Activation of the Na(+)-K(+)-2Cl(-)-cotransporter (NKCC2) and the Na(+)-Cl(-)-cotransporter (NCC) by vasopressin includes their… 
Highly Cited
2013
Highly Cited
2013
Differential regulation of Na+ transporters along nephron during ANG II-dependent hypertension: distal stimulation counteracted by proximal inhibition.
During angiotensin II (ANG II)-dependent hypertension, ANG II stimulates, while hypertension inhibits, Na(+) transporter activity… 
Highly Cited
2012
Highly Cited
2012
Cotransport of water by Na+–K+–2Cl− cotransporters expressed in Xenopus oocytes: NKCC1 versus NKCC2
•  It is a fundamental, yet unsolved physiological question how water transport is coupled to ion transport. •  Na+–K+–2Cl… 
Highly Cited
2011
Highly Cited
2011
Activation of the Bumetanide-sensitive Na+,K+,2Cl− Cotransporter (NKCC2) Is Facilitated by Tamm-Horsfall Protein in a Chloride-sensitive Manner*
Active transport of NaCl across thick ascending limb (TAL) epithelium is accomplished by Na+,K+,2Cl− cotransporter (NKCC2). The… 
Review
2011
Review
2011
Molecular regulation of NKCC2 in the thick ascending limb.
The kidney plays an essential role in blood pressure regulation by controlling short-term and long-term NaCl and water balance… 
Highly Cited
2009
Highly Cited
2009
cAMP Stimulates Apical Exocytosis of the Renal Na+-K+-2Cl− Cotransporter NKCC2 in the Thick Ascending Limb
The apical renal Na+-K+-2Cl− cotransporter NKCC2 mediates NaCl absorption by the thick ascending limb (TAL) of Henle's loop. cAMP… 
Highly Cited
2007
Highly Cited
2007
Regulation of the renal-specific Na+-K+-2Cl- co-transporter NKCC2 by AMP-activated protein kinase (AMPK).
The renal-specific NKCC2 (Na+-K+-2Cl- co-transporter 2) is regulated by changes in phosphorylation state, however, the… 
Highly Cited
2006
Highly Cited
2006
cAMP increases surface expression of NKCC2 in rat thick ascending limbs: role of VAMP.
  • P. Ortiz
  • AJP - Renal Physiology
  • 2006
  • Corpus ID: 24836865
NaCl absorption by the thick ascending limb of Henle's loop (TAL) is mediated by the apical Na-K-2Cl cotransporter NKCC2. cAMP… 
Highly Cited
2002
Highly Cited
2002
Clinical presentation of genetically defined patients with hypokalemic salt-losing tubulopathies.
Highly Cited
2002
Highly Cited
2002
Rat NKCC2/NKCC1 cotransporter selectivity for loop diuretic drugs
Abstract. It is generally assumed that bumetanide possesses some selectivity for the renal Na-K-Cl cotransporter NKCC2, although… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)