Small Molecule Libraries

Known as: chemical library, Libraries, Small Molecule, Libraries, Chemical 
Large collections of small molecules (molecular weight about 600 or less), of similar or diverse nature which are used for high-throughput screening… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2018
05010015019892018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
The pervasive influence of secreted Wnt signaling proteins in tissue homeostasis and tumorigenesis has galvanized efforts to… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Histone lysine methylation has important roles in the organization of chromatin domains and the regulation of gene expression. To… (More)
Is this relevant?
Highly Cited
2006
Highly Cited
2006
A cell-based screen of chemical libraries was carried out to identify small molecules that control the self-renewal of ES cells… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2006
Highly Cited
2006
High-throughput screening (HTS) of chemical compounds to identify modulators of molecular targets is a mainstay of pharmaceutical… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Renal cell carcinomas (RCC) commonly retain wild-type but functionally inactive p53, which is repressed by an unknown dominant… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
In tumors that retain wild-type p53, its tumor-suppressor function is often impaired as a result of the deregulation of HDM-2… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Apoptosis resistance commonly occurs in cancers, preventing activation of Caspase family cell death proteases. XIAP is an… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Myc is a transcriptional regulator of the basic helix-loop-helix leucine zipper protein family. It has strong oncogenic potential… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Tumorigenesis results from events that impinge on a variety of collaborating metabolic pathways. To assess their role in this… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
The ability to identify active compounds (³hits²) from large chemical libraries accurately and rapidly has been the ultimate goal… (More)
Is this relevant?