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Smad Proteins

Known as: Mothers Against Decapentaplegic Homolog, Sma- and Mad-Related Proteins, Smad Proteins [Chemical/Ingredient] 
A family of proteins that are involved in the translocation of signals from TGF-BETA RECEPTORS; BONE MORPHOGENETIC PROTEIN RECEPTORS; and other… 
National Institutes of Health

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DAF-3 protein, C elegans
In BloodProcess of secretionagonistsantagonists & inhibitors

Papers overview

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Highly Cited
2014
Highly Cited
2014
Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β–SMAD3 pathway in non-small cell lung adenocarcinoma
Significance Epithelial–mesenchymal transition (EMT) is a transdifferentiation program implicated in tumor cell dissemination… 
Highly Cited
2014
Highly Cited
2014
Losartan inhibits endothelial-to-mesenchymal transformation in mitral valve endothelial cells by blocking transforming growth factor-β-induced phosphorylation of ERK.
2014
2014
PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway.
Highly Cited
2014
Highly Cited
2014
Effect of microRNA‐145 on IL‐1β‐induced cartilage degradation in human chondrocytes
Highly Cited
2013
Highly Cited
2013
MicroRNA-181a Suppresses Mouse Granulosa Cell Proliferation by Targeting Activin Receptor IIA
Activin, a member of the transforming growth factor-β superfamily, promotes the growth of preantral follicles and the… 
Highly Cited
2011
Highly Cited
2011
Myostatin induces degradation of sarcomeric proteins through a Smad3 signaling mechanism during skeletal muscle wasting.
Ubiquitination-mediated proteolysis is a hallmark of skeletal muscle wasting manifested in response to negative growth factors… 
Highly Cited
2005
Highly Cited
2005
The Integral Inner Nuclear Membrane Protein MAN1 Physically Interacts with the R-Smad Proteins to Repress Signaling by the Transforming Growth Factor-β Superfamily of Cytokines*
Smad proteins are critical intracellular mediators of the transforming growth factor-β, bone morphogenic proteins (BMPs), and… 
Highly Cited
2004
Highly Cited
2004
CHIP Mediates Degradation of Smad Proteins and Potentially Regulates Smad-Induced Transcription
ABSTRACT Transforming growth factor beta (TGF-β)/bone morphogenetic protein (BMP) family ligands interact with specific membrane… 
Highly Cited
2002
Highly Cited
2002
Transcription activation of FLRG and follistatin by activin A, through Smad proteins, participates in a negative feedback loop to modulate activin A function
Signaling of TGFβ family members such as activin is tightly regulated by soluble binding proteins. Follistatin binds to activin A… 
Highly Cited
1997
Highly Cited
1997
Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.
Upon ligand binding, the receptors of the TGFbeta family phosphorylate Smad proteins, which then move into the nucleus where they… 
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