S. Dowdy

Publications176
h-index68
Citations21,396
Highly Influential Citations751
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In vivo protein transduction: delivery of a biologically active protein into the mouse.
TLDR
It is shown that intraperitoneal injection of the 120-kilodalton beta-galactosidase protein, fused to the protein transduction domain from the human immunodeficiency virus TAT protein, results in delivery of the biologically active fusion protein to all tissues in mice, including the brain.
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Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis
TLDR
It is shown that after an initial ionic cell-surface interaction, TAT-fusion proteins are rapidly internalized by lipid raft–dependent macropinocytosis, and a transducible, pH-sensitive, fusogenic dTAT-HA2 peptide is developed that markedly enhanced Tat-Cre escape from macropinosomes.
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CDK inhibitors: cell cycle regulators and beyond.
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Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration
TLDR
Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27 Kip1 induces cell migration and promotes cell migration in mice.
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Physical interaction of the retinoblastoma protein with human D cyclins
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Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo.
TLDR
It is reported here that the modeled structure of the TAT PTD is a strong amphipathic helix and a series of synthetic PTDs are synthesized that strengthen the alpha-helical content and optimize the placement of arginine residues.
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Cationic TAT peptide transduction domain enters cells by macropinocytosis.
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Function of a human cyclin gene as an oncogene.
TLDR
In cultured cells, a cDNA clone of the cyclin D1 gene can contribute to cell transformation by complementing a defective adenovirus E1A oncogene, suggesting a similar role in tumor progression in vivo.
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Protein transduction: unrestricted delivery into all cells?
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Protein transduction technology.
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