Sirtuins

Known as: Sirtuins [Chemical/Ingredient], Sir2-like Proteins, Silent Mating Type Information Regulator 2 like Proteins 
A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2018
05020002018

Papers overview

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Review
2015
Review
2015
Western societies are aging due to an increasing life span, decreased birth rates, and improving social and health conditions. On… (More)
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Highly Cited
2013
Highly Cited
2013
Mammalian sirtuins (SIRT1 through SIRT7) are members of a highly conserved family of NAD(+)-dependent protein deacetylases that… (More)
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2012
2012
Sirtuins are protein deacetylases regulating metabolism, stress responses, and aging processes, and they were suggested to… (More)
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Highly Cited
2011
Highly Cited
2011
Sirtuins are NAD-dependent deacetylases that are highly conserved from bacteria to human and SIR2 was originally shown to extend… (More)
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Highly Cited
2009
Highly Cited
2009
Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) belong to the family of NAD+ (nicotinamide adenine dinucleotide-positive)-dependent class… (More)
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Highly Cited
2008
Highly Cited
2008
The enzymes of the Sirtuin family of nicotinamide-adenine-dinucleotide-dependent protein deacetylases are emerging key players in… (More)
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Highly Cited
2008
Highly Cited
2008
In yeast, worms, and flies, an extra copy of the gene encoding the Sirtuin Sir2 increases metabolic efficiency, as does… (More)
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Highly Cited
2006
Highly Cited
2006
Sirtuins are genes implicated in cellular and organismal ageing. Consequently, they are speculated to be involved in diseases of… (More)
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Highly Cited
2005
Highly Cited
2005
Activation of NAD-dependent deacetylases, or Sirtuins, prolongs life span and mimics the effects of caloric restriction in yeast… (More)
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Highly Cited
2000
Highly Cited
2000
Sirtuins (Sir2-like proteins) are present in prokaryotes and eukaryotes. Here, two new human sirtuins (SIRT6 and SIRT7) are found… (More)
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