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Sirtuins

Known as: Sirtuins [Chemical/Ingredient], Sir2-like Proteins, Silent Mating Type Information Regulator 2 like Proteins 
A homologous family of regulatory enzymes that are structurally related to the protein silent mating type information regulator 2 (Sir2) found in… 
National Institutes of Health

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In BloodProcess of secretionSilent Information Regulator Proteins, Saccharomyces cerevisiaeantagonists & inhibitors

Papers overview

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Review
2017
Review
2017
Sirtuins as modifiers of Parkinson's disease pathology
Parkinson's disease (PD) is the most common movement disorder associated with the elderly which, other than symptomatic therapies… 
Review
2014
Review
2014
Systemic regulation of mammalian ageing and longevity by brain sirtuins
Sirtuins have been implicated in the ageing process in a variety of organisms, but their role in mammalian ageing remains… 
Highly Cited
2014
Highly Cited
2014
Overexpression of Mitochondrial Sirtuins Alters Glycolysis and Mitochondrial Function in HEK293 Cells
SIRT3, SIRT4, and SIRT5 are mitochondrial deacylases that impact multiple facets of energy metabolism and mitochondrial function… 
Review
2010
Review
2010
Sirtuins and their relevance to the kidney.
Sirtuins (silent information regulator 2 [Sir2] proteins) belong to an ancient family of evolutionary conserved nicotinamide… 
Review
2010
Review
2010
Sirtuins: common targets in aging and in neurodegeneration.
Aging has been a subject of interest since primordial times. More recently, it became clear that aging is the major known risk… 
2009
2009
Sirtuins at the Breaking Point: SIRT6 in DNA Repair
Aging is the accumulation of unrepaired damage to cellular and organismal components over time. Damage to nuclear DNA likely… 
Review
2009
Review
2009
Pharmaceutical strategies for activating sirtuins.
The sirtuins are protein modifying enzymes widely distributed in all forms of life. The sirtuins are principally NAD(+)-dependent… 
2009
2009
A fluorometric assay of SIRT1 deacetylation activity through quantification of nicotinamide adenine dinucleotide.
Highly Cited
2008
Highly Cited
2008
Mammalian sirtuin 1 is involved in the protective action of dietary saturated fat against alcoholic fatty liver in mice.
This study was undertaken to elucidate the mechanism underlying the protective effect of a high saturated fat (HSF) diet against… 
Highly Cited
2006
Highly Cited
2006
The structural basis of sirtuin substrate affinity.
Sirtuins comprise a family of enzymes that catalyze the deacetylation of acetyllysine side chains in a reaction that consumes NAD… 
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