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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
- S. Imai, Christopher M. Armstrong, M. Kaeberlein, L. Guarente
- Biology, ChemistryNature
- 17 February 2000
TLDR
hSIR2SIRT1 Functions as an NAD-Dependent p53 Deacetylase
- H. Vaziri, S. Dessain, R. Weinberg
- Biology, ChemistryCell
- 19 October 2001
Negative control of p53 by Sir2alpha promotes cell survival under stress.
- J. Luo, A. Nikolaev, W. Gu
- BiologyCell
- 2001
TLDR
The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells*
- Javier R. Revollo, Andrew A. Grimm, S. Imai
- BiologyJournal of Biological Chemistry
- 3 December 2004
TLDR
Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.
- J. Yoshino, K. F. Mills, M. J. Yoon, S. Imai
- Biology, MedicineCell metabolism
- 5 October 2011
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.
- Javier R Revollo, A. Körner, S. Imai
- Biology, MedicineCell metabolism
- 7 November 2007
Negative Control of p53 by Sir2α Promotes Cell Survival under Stress
- Jianyuan Luo, A. Nikolaev, W. Gu
- BiologyCell
- 19 October 2001
Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis
- K. Ramsey, J. Yoshino, J. Bass
- BiologyScience
- 1 May 2009
TLDR
NAD+ and sirtuins in aging and disease.
- S. Imai, L. Guarente
- BiologyTrends in cell biology
- 1 August 2014
Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.
- Kathryn A Moynihan, Andrew A. Grimm, S. Imai
- Biology, MedicineCell metabolism
- 1 August 2005
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