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Sirtuin 3

Known as: Silent Mating Type Information Regulation 2 Homolog 3, Sirtuin 3 [Chemical/Ingredient] 
A sirtuin family member found primarily in MITOCHONDRIA. It is a multifunctional enzyme that contains a NAD-dependent deacetylase activity that is… Expand
National Institutes of Health

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Related topics

8 relations
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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Broader (1)

SIRT3 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Pinocembrin from Penthorum chinense Pursh suppresses hepatic stellate cells activation through a unified SIRT3‐TGF‐&bgr;‐Smad signaling pathway
&NA; The inactivation of hepatic stellate cells (HSCs) has been verified to be an effective therapeutic strategy for treatment of… Expand
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2018
2018
SIRT3 prevents angiotensin II-induced renal tubular epithelial-mesenchymal transition by ameliorating oxidative stress and mitochondrial dysfunction
Silent mating type information regulation 2 homolog 3 (SIRT3) is a major protective mediator that ameliorates oxidative stress… Expand
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2018
2018
Sirtuin 3 attenuates amyloid-β induced neuronal hypometabolism
Alzheimer’s disease (AD) is manifested by regional cerebral hypometabolism. Sirtuin 3 (Sirt3) is localized in mitochondria and… Expand
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2018
2018
SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3‐9 homolog 1 and SET domain…
Hepatitis B virus (HBV) infection remains a major health problem worldwide. Maintenance of the covalently closed circular DNA… Expand
Review
2018
Review
2018
Reactive Oxygen and Nitrogen Species Regulate Key Metabolic, Anabolic, and Catabolic Pathways in Skeletal Muscle
Reactive oxygen and nitrogen species (RONS) are important cellular regulators of key physiological processes in skeletal muscle… Expand
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2017
2017
Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism
Parkinson's disease (PD) is a neurodegenerative movement disorder, which affects approximately 1-2% of the population over… Expand
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2017
2017
Sirtuin 3 is required for osteogenic differentiation through maintenance of PGC-1ɑ-SOD2-mediated regulation of mitochondrial function
Osteogenic differentiation is crucial for the maintenance of bone homeostasis. Sirtuin 3 (SIRT3), a member of sirtuins family… Expand
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2017
2017
SOD2 and Sirt3 Control Osteoclastogenesis by Regulating Mitochondrial ROS
Reactive oxygen species (ROS) are an indispensable element of cellular signal transduction in various cell types, including bone… Expand
2014
2014
STRESS‐Responsive Deacetylase SIRT3 is Up‐Regulated by Areca Nut Extract‐Induced Oxidative Stress in Human Oral Keratinocytes
Areca chewing is an important environmental risk factor for development of oral premalignant lesions and cancer. Epidemiological… Expand
Highly Cited
2009
Highly Cited
2009
Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
Sirtuin 3 (SIRT3) is a member of the sirtuin family of proteins that promote longevity in many organisms. Increased expression of… Expand
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