Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Silencer Elements, Transcriptional

Known as: Element, Silencer, Transcriptional Silencer Elements, Element, Transcriptional Silencer 
Nucleic acid sequences that are involved in the negative regulation of GENETIC TRANSCRIPTION by chromatin silencing.
National Institutes of Health

Related topics

Related topics

3 relations
aspects of radiation effectsphysiological aspects

Narrower (1)

proU silencer

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
lncRNAs transactivate Staufen1-mediated mRNA decay by duplexing with 3'UTRs via Alu elements
Staufen 1 (STAU1)-mediated messenger RNA decay (SMD) involves the degradation of translationally active mRNAs whose 3… Expand
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.
Huntingtin is a protein that is mutated in Huntington's disease (HD), a dominant inherited neurodegenerative disorder. We… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2006
Highly Cited
2006
RNA polymerase III transcribes human microRNAs
Prior work demonstrates that mammalian microRNA (miRNA or miR) expression requires RNA polymerase II (Pol II). However, the… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron.
Humans have two nearly identical copies of the Survival Motor Neuron (SMN) gene, SMN1 and SMN2. In spinal muscular atrophy (SMA… Expand
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization.
The nuclease hypersensitivity element III(1) (NHE III(1)) of the c-MYC promoter strongly controls the transcriptional activity of… Expand
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
Huntingtin protein is mutated in Huntington disease. We previously reported that wild-type but not mutant huntingtin stimulates… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Perinuclear localization of chromatin facilitates transcriptional silencing
Transcriptional silencing in Saccharomyces cerevisiae at the HM mating-type loci and telomeres occurs through the formation of a… Expand
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene.
The identification of a common cis-acting silencer element, a neuron-restrictive silencer element (NRSE), in multiple neuron… Expand
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1995
Highly Cited
1995
The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes.
The neuron-restrictive silencer factor (NRSF) binds a DNA sequence element, called the neuron-restrictive silencer element (NRSE… Expand
Is this relevant?
Highly Cited
1995
Highly Cited
1995
REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
Expression of the type II voltage-dependent sodium channel gene is restricted to neurons by a silencer element active in… Expand
  • figure 2
  • figure 1
  • figure 3
  • figure 5
  • figure 6
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE