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Silencer Elements, Transcriptional

Known as: Element, Silencer, Transcriptional Silencer Elements, Element, Transcriptional Silencer 
Nucleic acid sequences that are involved in the negative regulation of GENETIC TRANSCRIPTION by chromatin silencing.
National Institutes of Health

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Related topics

3 relations
aspects of radiation effectsphysiological aspects

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proU silencer

Papers overview

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Highly Cited
2011
Highly Cited
2011
lncRNAs transactivate Staufen1-mediated mRNA decay by duplexing with 3'UTRs via Alu elements
Staufen 1 (STAU1)-mediated messenger RNA decay (SMD) involves the degradation of translationally active mRNAs whose 3… Expand
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Highly Cited
2010
Highly Cited
2010
Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model.
Increasing survival of motor neuron 2, centromeric (SMN2) exon 7 inclusion to express more full-length SMN protein in motor… Expand
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Highly Cited
2006
Highly Cited
2006
RNA polymerase III transcribes human microRNAs
Prior work demonstrates that mammalian microRNA (miRNA or miR) expression requires RNA polymerase II (Pol II). However, the… Expand
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Highly Cited
2005
Highly Cited
2005
Solution structure of the biologically relevant G-quadruplex element in the human c-MYC promoter. Implications for G-quadruplex stabilization.
The nuclease hypersensitivity element III(1) (NHE III(1)) of the c-MYC promoter strongly controls the transcriptional activity of… Expand
Highly Cited
2003
Highly Cited
2003
Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes
Huntingtin protein is mutated in Huntington disease. We previously reported that wild-type but not mutant huntingtin stimulates… Expand
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Highly Cited
1998
Highly Cited
1998
Perinuclear localization of chromatin facilitates transcriptional silencing
Transcriptional silencing in Saccharomyces cerevisiae at the HM mating-type loci and telomeres occurs through the formation of a… Expand
Highly Cited
1996
Highly Cited
1996
Identification of potential target genes for the neuron-restrictive silencer factor.
The neuron-restrictive silencer factor (NRSF) represses transcription of several neuronal genes in nonneuronal cells by binding… Expand
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Highly Cited
1995
Highly Cited
1995
The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes
The neuron-restrictive silencer factor (NRSF) binds a DNA sequence element, called the neuron-restrictive silencer element (NRSE… Expand
Highly Cited
1995
Highly Cited
1995
REST: A mammalian silencer protein that restricts sodium channel gene expression to neurons
Expression of the type II voltage-dependent sodium channel gene is restricted to neurons by a silencer element active in… Expand
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Highly Cited
1983
Highly Cited
1983
Vectors for P element-mediated gene transfer in Drosophila.
We have constructed and tested several new vectors for P element-mediated gene transfer. These vectors contain restriction sites… Expand
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