Signaling Lymphocytic Activation Molecule, human

Known as: CD150 antigen, human, SLAMF1 protein, human, signaling lymphocytic activation molecule family member 1, human 
Signaling lymphocytic activation molecule (335 aa, ~37 kDa) is encoded by the human SLAMF1 gene. This protein is involved in immune cell regulation… (More)
National Institutes of Health

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5 relations
SLAMF1 geneSignal TransductionSignaling Pathway Gene

Broader (2)

Signaling Lymphocytic Activation Molecule FamilySignaling Lymphocytic Activation Molecule Family Member 1

Papers overview

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Highly Cited
2010
Highly Cited
2010
Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150).
CD4 T cell help is critical for the generation and maintenance of germinal centers (GCs), and T follicular helper (T(FH)) cells… (More)
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2008
2008
Control of T lymphocyte signaling by Ly108, a signaling lymphocytic activation molecule family receptor implicated in autoimmunity.
The signaling lymphocytic activation molecule family of receptors has been implicated in the pathophysiology of autoimmunity in… (More)
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Highly Cited
2005
Highly Cited
2005
Signaling lymphocytic activation molecule-associated protein controls NKT cell functions.
X-linked lymphoproliferative disease (XLP) is a fatal immunological disorder that typically manifests following EBV infection… (More)
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Highly Cited
2001
Highly Cited
2001
Measles viruses on throat swabs from measles patients use signaling lymphocytic activation molecule (CDw150) but not CD46 as a cellular receptor.
Both CD46 and signaling lymphocytic activation molecule (SLAM) have been shown to act as cellular receptors for measles virus (MV… (More)
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Highly Cited
2001
Highly Cited
2001
Signaling lymphocytic activation molecule is expressed on CD40 ligand-activated dendritic cells and directly augments production of inflammatory cytokines.
Dendritic cells (DC) comprise a key part of the innate immune system that, upon activation, profoundly influences the nature of… (More)
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2001
2001
Signaling lymphocytic activation molecule (SLAM) regulates T cellular cytotoxicity.
Signaling lymphocytic activation molecule (SLAM) is a CD2-related surface receptor expressed by activated T cells and B cells… (More)
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Highly Cited
1999
Highly Cited
1999
Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP.
The genetic defect in X-linked lymphoproliferative syndrome (XLP) is the Src homology 2 domain-containing protein SAP. SAP… (More)
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Highly Cited
1997
Highly Cited
1997
Soluble and Membrane-bound Forms of Signaling Lymphocytic Activation Molecule (SLAM) Induce Proliferation and Ig Synthesis by Activated Human B Lymphocytes
In this study it is shown that both membrane-bound and soluble forms of signaling lymphocytic activation molecule (SLAM) induce… (More)
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Highly Cited
1997
Highly Cited
1997
Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, cyclosporin A-sensitive T cell proliferation and IFN-gamma production.
The expression and function of the novel signaling lymphocytic activation molecule (SLAM) are described. SLAM is present on… (More)
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1997
1997
Reversal of human allergic T helper 2 responses by engagement of signaling lymphocytic activation molecule.
Allergen-specific Th2 cells accumulate at high frequencies in the skin of patients with atopic dermatitis (AD), where they… (More)
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