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Short Hairpin RNA

Known as: RNA, Short Hairpin, Small Hairpin RNA, Hairpin RNA, Short 
An artificial RNA molecule with a tight hairpin turn that can be used to silence target gene expression via RNA interference (RNAi).
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

RNA, Small Interfering

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
A Rapid and Scalable System for Studying Gene Function in Mice Using Conditional RNA Interference
Highly Cited
2010
Highly Cited
2010
SIRT4 Regulates Fatty Acid Oxidation and Mitochondrial Gene Expression in Liver and Muscle Cells
SIRT4, a member of the sirtuin family, has been implicated in the regulation of insulin secretion by modulation of glutamate… 
Highly Cited
2008
Highly Cited
2008
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation.
Highly Cited
2007
Highly Cited
2007
VEGF-specific short hairpin RNA-expressing oncolytic adenovirus elicits potent inhibition of angiogenesis and tumor growth.
RNA interference is being developed to treat cancer. Although highly target specific, its use has been limited by its short… 
Highly Cited
2006
Highly Cited
2006
Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma: implications for angiogenesis and glioma cell invasion
Hypoxia and hypoxia-inducible factor-1 (HIF-1) play a critical role in glioblastoma multiforme (GBMs). CXCR4 is involved in… 
Highly Cited
2006
Highly Cited
2006
The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells.
Transforming growth factor beta (TGF-beta) can act as suppressor and promoter of cancer progression. Intracellular Smad proteins… 
Highly Cited
2006
Highly Cited
2006
Identification of CD63 as a tissue inhibitor of metalloproteinase‐1 interacting cell surface protein
This study identified CD63, a member of the tetraspanin family, as a TIMP‐1 interacting protein by yeast two‐hybrid screening… 
Highly Cited
2004
Highly Cited
2004
Lamellipodial Versus Filopodial Mode of the Actin Nanomachinery Pivotal Role of the Filament Barbed End
Highly Cited
2004
Highly Cited
2004
Short-term cytotoxic effects and long-term instability of RNAi delivered using lentiviral vectors
BackgroundRNA interference (RNAi) can potently reduce target gene expression in mammalian cells and is in wide use for loss-of… 
Highly Cited
1998
Highly Cited
1998
Cross-coupled microstrip hairpin-resonator filters
A new class of cross-coupled planar microwave filters using microstrip hairpin resonators is introduced. The realization of bath… 
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