Short Hairpin RNA

Known as: RNA, Short Hairpin, Small Hairpin RNA, Hairpin RNA, Short 
An artificial RNA molecule with a tight hairpin turn that can be used to silence target gene expression via RNA interference (RNAi).
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Shortly after the cellular mechanism of RNA interference (RNAi) was first described, scientists began using this powerful… (More)
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Highly Cited
2007
Highly Cited
2007
RNA interference is being developed to treat cancer. Although highly target specific, its use has been limited by its short… (More)
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Highly Cited
2006
Highly Cited
2006
RNA interference (RNAi) is a universal and evolutionarily conserved phenomenon of post-transcriptional gene silencing by means of… (More)
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Highly Cited
2006
Highly Cited
2006
RNA-interference (RNAi) is a potent mechanism, conserved from plants to humans for specific silencing of genes, which holds… (More)
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Highly Cited
2006
Highly Cited
2006
We present an integrated approach to identify genetic mechanisms that control self-renewal in mouse embryonic stem cells. We use… (More)
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Highly Cited
2006
Highly Cited
2006
Specific, potent, and sustained short hairpin RNA (shRNA)-mediated gene silencing is crucial for the successful application of… (More)
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Highly Cited
2005
Highly Cited
2005
The advent of RNA interference has led to the ability to interfere with gene expression and greatly expanded our ability to… (More)
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Highly Cited
2005
Highly Cited
2005
Plasmids or viral vectors that express short hairpin RNAs (shRNAs) have emerged as important tools for the stable inhibition of… (More)
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Highly Cited
2005
Highly Cited
2005
RNA interference (RNAi) mediates gene silencing in many eukaryotes and has been widely used to investigate gene functions. A… (More)
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Highly Cited
2004
Highly Cited
2004
We have generated two lentiviral vectors for conditional, Cre-lox-regulated, RNA interference. One vector allows for conditional… (More)
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