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Serotonin 5-HT4 Receptor Antagonists

Known as: 5-HT4 Antagonist, Serotonin 5 HT4 Receptor Antagonists, Antagonists, 5-HT4 
Drugs that bind to but do not activate SEROTONIN 5-HT4 RECEPTORS, thereby blocking the actions of SEROTONIN or SEROTONIN RECEPTOR AGONISTS.
National Institutes of Health

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Papers overview

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Review
2016
Review
2016
Serotonergic Drugs: Agonists/Antagonists at Specific Serotonergic Subreceptors for the Treatment of Cognitive, Depressant and Psychotic Symptoms in Alzheimer's Disease.
BACKGROUND Alzheimer's disease is a neurodegenerative disease showing alterations in classical neurotransmitters, above all in… 
2015
2015
Luminal 5‐HT stimulates colonic bicarbonate secretion in rats
The bioactive monoamine 5‐HT, implicated in the pathogenesis of functional gastrointestinal disorders, is abundantly synthesized… 
2013
2013
Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist.
2002
2002
Molecular Design Based on 3D-Pharmacophore. Application to 5-HT4 Receptor
A definition of a pharmacophore for the 5-HT4 antagonist was carried out by considering a three-dimensional model which… 
2002
2002
5‐HT4 receptors in the hippocampus modulate rat locomotor activity
In the present study, the ability of 5‐hydroxytryptamine‐4 (5‐HT4) receptors in the hippocampus to enhance locomotor activity in… 
1999
1999
5-HT4 receptors in isolated human corpus cavernosum?
The novel serotonin subtype-4 (5-HT4) receptor agonist, SC53116 (SC), produced a limited relaxation of noradrenaline (NA) pre… 
1999
1999
Identification of SK-951, a novel benzofuran derivative, as an agonist to 5-HT4 receptors.
The pharmacological profile of SK-951 ((-)4-amino-N-[2-(1-azabicyclo[3.3.0]octan-5-yl) ethyl]-5-chloro-2,3-dihydro-2-methylbenzo… 
1997
1997
Several Receptor Subtypes Contribute to 5‐Hydroxytryptamine‐induced Secretion by Rat Ileum In‐vitro
The receptors contributing to 5‐hydroxytryptamine (5‐HT)‐induced secretion by rat ileum were investigated in‐vitro using… 
1996
1996
5-Hydroxytryptamine-induced Cl- transport is mediated by 5-HT3 and 5-HT4 receptors in the rat distal colon.
1994
1994
The 5-HT4 receptor mediates 5-hydroxytryptamine-induced rise in short circuit current in the human jejunum in vitro.
BACKGROUND 5-Hydroxytryptamine (5-HT) is a potent intestinal secretagogue for chloride and a mediator of diarrhea in the… 
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