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Serine Protease Hepsin

Known as: EC 3.4.21.106 
Serine protease hepsin (417 aa, ~45 kDa) is encoded by the human HPN gene. This protein is involved in proteolysis.
National Institutes of Health

Papers overview

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2019
2019
Uromodulin is a zona pellucida-type protein essentially produced in the thick ascending limb (TAL) of the mammalian kidney. It is… Expand
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Highly Cited
2015
Highly Cited
2015
Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal epithelial cells and it plays key roles… Expand
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2012
2012
The serine protease hepsin is highly upregulated in prostate cancer and is implicated in tumor progression. Therefore, specific… Expand
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2011
2011
The matrix metalloproteinase (MMP) family is believed to play a role in the ovulatory process because MMP inhibitors block oocyte… Expand
2009
2009
The transmembrane serine protease hepsin is one of the most highly upregulated genes in prostate cancer. Here, we investigated… Expand
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2009
2009
The transmembrane serine protease hepsin is one of the most highly upregulated genes in prostate cancer. Here, we investigated… Expand
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2008
2008
BACKGROUND Hepsin is a type II transmembrane serine protease originally identified in the human liver as a cDNA clone. Hepsin was… Expand
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2005
2005
Progression of prostate cancer to androgen independence remains the primary obstacle to improved survival. The development of… Expand
Highly Cited
2001
Highly Cited
2001
Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this fact, many of the genetic changes that… Expand
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Highly Cited
1997
Highly Cited
1997
Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow… Expand