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Serine Protease Hepsin

Known as: EC 3.4.21.106 
Serine protease hepsin (417 aa, ~45 kDa) is encoded by the human HPN gene. This protein is involved in proteolysis.
National Institutes of Health

Related topics

Related topics

14 relations
Cell Growth RegulationEnzyme GeneHPN geneHydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Hepsin-mediated Processing of Uromodulin is Crucial for Salt-sensitivity and Thick Ascending Limb Homeostasis
Uromodulin is a zona pellucida-type protein essentially produced in the thick ascending limb (TAL) of the mammalian kidney. It is… 
2019
2019
Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells
The serine protease hepsin is frequently overexpressed in human prostate cancer (PCa) and is associated with matrix degradation… 
Highly Cited
2015
Highly Cited
2015
The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin
Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal epithelial cells and it plays key roles… 
2012
2012
An allosteric anti-hepsin antibody derived from a constrained phage display library.
The serine protease hepsin is highly upregulated in prostate cancer and is implicated in tumor progression. Therefore, specific… 
2011
2011
Identification of Hepsin and Protein Disulfide Isomerase A3 as Targets of Gelatinolytic Action in Rat Ovarian Granulosa Cells During the Periovulatory Period1
The matrix metalloproteinase (MMP) family is believed to play a role in the ovulatory process because MMP inhibitors block oocyte… 
Highly Cited
2009
Highly Cited
2009
Pegylated kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis.
The transmembrane serine protease hepsin is one of the most highly upregulated genes in prostate cancer. Here, we investigated… 
2008
2008
Expression of the serine protease hepsin and clinical outcome of human endometrial cancer.
BACKGROUND Hepsin is a type II transmembrane serine protease originally identified in the human liver as a cDNA clone. Hepsin was… 
2005
2005
Differential expression of 37 selected genes in hormone‐refractory prostate cancer using quantitative taqman real‐time RT‐PCR
Progression of prostate cancer to androgen independence remains the primary obstacle to improved survival. The development of… 
Highly Cited
2001
Highly Cited
2001
Expression profiling reveals hepsin overexpression in prostate cancer.
Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this fact, many of the genetic changes that… 
Highly Cited
1997
Highly Cited
1997
Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer.
Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow… 
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