FAQ

Serine Protease Hepsin

Known as: EC 3.4.21.106 
Serine protease hepsin (417 aa, ~45 kDa) is encoded by the human HPN gene. This protein is involved in proteolysis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2015
0119972015

Related topics

Related topics

15 relations
Cell Growth RegulationEnzyme GeneHPN geneHydrolase Gene
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Serine Protease Hepsin
Plasma membrane
Proteolysis
Negative Regulation of Apoptosis
Cell Growth Regulation
Inhibition of Cell Proliferation

Papers overview

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2015
2015
The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin
Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal epithelial cells and it plays key roles… (More)
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2012
2012
An allosteric anti-hepsin antibody derived from a constrained phage display library.
The serine protease hepsin is highly upregulated in prostate cancer and is implicated in tumor progression. Therefore, specific… (More)
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2011
2011
Identification of hepsin and protein disulfide isomerase A3 as targets of gelatinolytic action in rat ovarian granulosa cells during the periovulatory period.
The matrix metalloproteinase (MMP) family is believed to play a role in the ovulatory process because MMP inhibitors block oocyte… (More)
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2009
2009
Pegylated kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis.
The transmembrane serine protease hepsin is one of the most highly upregulated genes in prostate cancer. Here, we investigated… (More)
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2008
2008
Expression of the serine protease hepsin and clinical outcome of human endometrial cancer.
BACKGROUND Hepsin is a type II transmembrane serine protease originally identified in the human liver as a cDNA clone. Hepsin was… (More)
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Highly Cited
1997
Highly Cited
1997
Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer.
Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow… (More)
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