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Serine Protease Hepsin

Known as: EC 3.4.21.106 
Serine protease hepsin (417 aa, ~45 kDa) is encoded by the human HPN gene. This protein is involved in proteolysis.
National Institutes of Health

Related topics

Related topics

14 relations
Cell Growth RegulationEnzyme GeneHPN geneHydrolysis

Papers overview

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2020
2020
From in-silico to Experimental Validation: Tailoring Peptide Substrates for a Serine Protease.
Smart nanocarriers for the transport of drugs to tumor cells are nowadays of great interest for treating cancer. The use of… 
2019
2019
Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells
The serine protease hepsin is frequently overexpressed in human prostate cancer (PCa) and is associated with matrix degradation… 
2019
2019
Abstract 3484: Ras recruits oncogenic serine protease hepsin to disrupt mammary epithelial integrity
2012
2012
An allosteric anti-hepsin antibody derived from a constrained phage display library.
The serine protease hepsin is highly upregulated in prostate cancer and is implicated in tumor progression. Therefore, specific… 
2011
2011
Identification of Hepsin and Protein Disulfide Isomerase A3 as Targets of Gelatinolytic Action in Rat Ovarian Granulosa Cells During the Periovulatory Period1
The matrix metalloproteinase (MMP) family is believed to play a role in the ovulatory process because MMP inhibitors block oocyte… 
2009
2009
Experimental Therapeutics , Molecular Targets , and Chemical Biology Pegylated Kunitz Domain Inhibitor Suppresses Hepsin-Mediated Invasive Tumor Growth and Metastasis
The transmembrane serine protease hepsin is one of the most highly upregulated genes in prostate cancer. Here, we investigated… 
2008
2008
Expression of the serine protease hepsin and clinical outcome of human endometrial cancer.
BACKGROUND Hepsin is a type II transmembrane serine protease originally identified in the human liver as a cDNA clone. Hepsin was… 
Highly Cited
1997
Highly Cited
1997
Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer.
Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow… 
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