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Serine Protease Hepsin

Known as: EC 3.4.21.106 
Serine protease hepsin (417 aa, ~45 kDa) is encoded by the human HPN gene. This protein is involved in proteolysis.
National Institutes of Health

Papers overview

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2019
2019
Uromodulin is a zona pellucida-type protein essentially produced in the thick ascending limb (TAL) of the mammalian kidney. It is… Expand
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2015
2015
Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal epithelial cells and it plays key roles… Expand
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2012
2012
The serine protease hepsin is highly upregulated in prostate cancer and is implicated in tumor progression. Therefore, specific… Expand
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2011
2011
The matrix metalloproteinase (MMP) family is believed to play a role in the ovulatory process because MMP inhibitors block oocyte… Expand
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2009
2009
The transmembrane serine protease hepsin is one of the most highly upregulated genes in prostate cancer. Here, we investigated… Expand
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2009
2009
The transmembrane serine protease hepsin is one of the most highly upregulated genes in prostate cancer. Here, we investigated… Expand
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2008
2008
BACKGROUND Hepsin is a type II transmembrane serine protease originally identified in the human liver as a cDNA clone. Hepsin was… Expand
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2005
2005
Progression of prostate cancer to androgen independence remains the primary obstacle to improved survival. The development of… Expand
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Highly Cited
2001
Highly Cited
2001
Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this fact, many of the genetic changes that… Expand
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Highly Cited
1997
Highly Cited
1997
Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow… Expand
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