Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 210,177,744 papers from all fields of science
Search
Sign In
Create Free Account
Serine Protease Hepsin
Known as:
EC 3.4.21.106
Serine protease hepsin (417 aa, ~45 kDa) is encoded by the human HPN gene. This protein is involved in proteolysis.
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
14 relations
Cell Growth Regulation
Enzyme Gene
HPN gene
Hydrolysis
Expand
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Hepsin-mediated Processing of Uromodulin is Crucial for Salt-sensitivity and Thick Ascending Limb Homeostasis
E. Olinger
,
Jennifer Lake
,
+8 authors
O. Devuyst
Scientific Reports
2019
Corpus ID: 201283476
Uromodulin is a zona pellucida-type protein essentially produced in the thick ascending limb (TAL) of the mammalian kidney. It is…
Expand
2019
2019
Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells
Ramona Willbold
,
Katharina Wirth
,
T. Martini
,
H. Sültmann
,
C. Bolenz
,
R. Wittig
Cell Death and Disease
2019
Corpus ID: 199511932
The serine protease hepsin is frequently overexpressed in human prostate cancer (PCa) and is associated with matrix degradation…
Expand
Highly Cited
2015
Highly Cited
2015
The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin
Martina Brunati
,
S. Perucca
,
+16 authors
L. Rampoldi
eLife
2015
Corpus ID: 6282212
Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal epithelial cells and it plays key roles…
Expand
2012
2012
An allosteric anti-hepsin antibody derived from a constrained phage display library.
R. Ganesan
,
Yingnan Zhang
,
K. Landgraf
,
S. Lin
,
P. Moran
,
D. Kirchhofer
Protein engineering, design & selection : PEDS
2012
Corpus ID: 377374
The serine protease hepsin is highly upregulated in prostate cancer and is implicated in tumor progression. Therefore, specific…
Expand
2011
2011
Identification of Hepsin and Protein Disulfide Isomerase A3 as Targets of Gelatinolytic Action in Rat Ovarian Granulosa Cells During the Periovulatory Period1
K. Rosewell
,
Linah F. Al-Alem
,
Fei-xue Li
,
Brian P. Kelty
,
T. Curry
Biology of Reproduction
2011
Corpus ID: 23253996
The matrix metalloproteinase (MMP) family is believed to play a role in the ovulatory process because MMP inhibitors block oocyte…
Expand
Highly Cited
2009
Highly Cited
2009
Pegylated kunitz domain inhibitor suppresses hepsin-mediated invasive tumor growth and metastasis.
Wei Li
,
Bu-Er Wang
,
+9 authors
D. Kirchhofer
Cancer Research
2009
Corpus ID: 23717335
The transmembrane serine protease hepsin is one of the most highly upregulated genes in prostate cancer. Here, we investigated…
Expand
2008
2008
Expression of the serine protease hepsin and clinical outcome of human endometrial cancer.
T. Matsuo
,
K. Nakamura
,
+6 authors
Y. Hiramatsu
Anticancer Research
2008
Corpus ID: 12559172
BACKGROUND Hepsin is a type II transmembrane serine protease originally identified in the human liver as a cDNA clone. Hepsin was…
Expand
2005
2005
Differential expression of 37 selected genes in hormone‐refractory prostate cancer using quantitative taqman real‐time RT‐PCR
G. Fromont
,
L. Chêne
,
+6 authors
O. Cussenot
International Journal of Cancer
2005
Corpus ID: 12764060
Progression of prostate cancer to androgen independence remains the primary obstacle to improved survival. The development of…
Expand
Highly Cited
2001
Highly Cited
2001
Expression profiling reveals hepsin overexpression in prostate cancer.
J. Magee
,
T. Araki
,
+6 authors
J. Milbrandt
Cancer Research
2001
Corpus ID: 15790865
Prostate cancer is the most commonly diagnosed noncutaneous cancer in men. Despite this fact, many of the genetic changes that…
Expand
Highly Cited
1997
Highly Cited
1997
Hepsin, a cell surface serine protease identified in hepatoma cells, is overexpressed in ovarian cancer.
H. Tanimoto
,
Y. Yan
,
+5 authors
T. O'brien
Cancer Research
1997
Corpus ID: 36477648
Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE