Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells

@inproceedings{Willbold2019ExcessHP,
  title={Excess hepsin proteolytic activity limits oncogenic signaling and induces ER stress and autophagy in prostate cancer cells},
  author={Ramona Willbold and Katharina Wirth and Thomas Martini and Holger S{\"u}ltmann and Christian Bolenz and Rainer Wittig},
  booktitle={Cell Death & Disease},
  year={2019}
}
  • Ramona Willbold, Katharina Wirth, +3 authors Rainer Wittig
  • Published in Cell Death & Disease 2019
  • DOI:10.1038/s41419-019-1830-8
The serine protease hepsin is frequently overexpressed in human prostate cancer (PCa) and is associated with matrix degradation and PCa progression in mice. Curiously, low expression of hepsin is associated with poor survival in different cancer types, and transgenic overexpression of hepsin leads to loss of viability in various cancer cell lines. Here, by comparing isogenic transfectants of the PCa cell line PC-3 providing inducible overexpression of wild-type hepsin (HPN) vs. the protease… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 65 REFERENCES

Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2012
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

enhances apoptosis induced by ER stress aggravators in human pancreatic cancer cells

D. M. Schewe, J. A. Aguirre-Ghiso
  • 2016