Semustine

Known as: 1-(2-Chloroethyl)-3-(Trans-4-Methylcyclohexane)-1-Nitrosourea, Lomustine, methyl, Urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI) 
A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic… (More)
National Institutes of Health

Papers overview

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2006
2006
Severe graft-versus-host disease (GVHD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (ASCT… (More)
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1997
Highly Cited
1997
Nutrition has long been recognized as a prognostic and therapeutic determinant in patients with chronic liver disease (1) and was… (More)
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1994
Highly Cited
1994
BACKGROUND The combination of radiation therapy and chemotherapy with fluorouracil plus semustine after surgery has been… (More)
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1994
Highly Cited
1994
PURPOSE The purpose of this study was to evaluate the therapeutic effectiveness of fluorouracil (5-FU), doxorubicin, and methyl… (More)
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1988
Highly Cited
1988
Information is presented from 555 patients with Dukes B and C rectal cancers treated by curative resection who were entered into… (More)
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1984
Highly Cited
1984
In a prospective randomized Eastern Cooperative Oncology Group (ECOG) study, 53 eligible and evaluable patients with advanced… (More)
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1983
Highly Cited
1983
Recently, the RTOG and ECOG concluded a joint randomized study on malignant gliomas that was in progress for the past five years… (More)
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1983
1983
We evaluated the risk of acute nonlymphocytic leukemia, acute myelodysplastic syndrome, and preleukemia in 3633 patients with… (More)
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1980
Highly Cited
1980
Within three weeks of definitive surgical intervention, 467 patients with histologically proved malignant glioma were randomized… (More)
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1978
Highly Cited
1978
A series of studies were undertaken to evaluate the chemotherapeutic response to various antineoplastic drugs of human breast (MX… (More)
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