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Semustine
Known as:
1-(2-Chloroethyl)-3-(Trans-4-Methylcyclohexane)-1-Nitrosourea
, Lomustine, methyl
, Urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI)
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A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic…
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National Institutes of Health
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Related topics
Related topics
25 relations
Broader (1)
Antineoplastic Agents, Alkylating
Narrower (8)
FAMMe protocol
FME protocol
FMI protocol
FMT protocol
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In Blood
NCIt Antineoplastic Agent Terminology
agonists
analogs & derivatives
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
1995
Review
1995
Review of adjuvant chemotherapy for gastric cancer
T. Nakajima
World Journal of Surgery
1995
Corpus ID: 6499004
Controlled randomized studies that compared surgery alone to adjuvant chemotherapy for gastric cancer were reviewed. The amount…
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1990
1990
The quest for a predictive design of anticancer drugs
G. Sosnovsky
1990
Corpus ID: 53542406
Abstract
1989
1989
Degradation and disposal of some antineoplastic drugs.
G. Lunn
,
Eric B. Sansone
,
A. W. Andrews
,
L. Hellwig
Journal of Pharmacy and Science
1989
Corpus ID: 30383855
Bulk quantities and pharmaceutical preparations of the antineoplastic drugs carmustine (BCNU), lomustine (CCNU), chlorozotocin, N…
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1979
1979
Biologic activity of MCNU: a new antitumor agent.
S. Sekido
,
K. Ninomiya
,
M. Iwasaki
Cancer treatment reports
1979
Corpus ID: 36228674
A novel nitrosourea derivative, methyl-6-[[[(2-chloroethyl)nitrosoamino]carbonyl]-amino]-6-deoxy-alpha-D-glucopyranoside (MCNU…
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1979
1979
Phase II-III chemotherapy studies in advanced gastric cancer. Eastern Cooperative Oncology Group.
C. Moertel
,
P. Lavin
Cancer treatment reports
1979
Corpus ID: 7455362
In this study, 139 eligible and evaluable patients with advanced gastric cancer, measurable disease, and no prior chemotherapy…
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Highly Cited
1978
Highly Cited
1978
DNA cross-linking by in vivo treatment with 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea of sensitive and resistant human colon carcinoma xenograms in nude mice.
C. B. Thomas
,
R. Osieka
,
K. Kohn
Cancer Research
1978
Corpus ID: 19381415
The DNA alkaline elution technique provides a sensitive assay for the effects of DNA-damaging drugs in mammalian cells. We have…
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1978
1978
Evaluation of single-agent therapy in human colorectal tumour xenografts.
P. Houghton
,
J. Houghton
British Journal of Cancer
1978
Corpus ID: 2601569
The response of 6 human colorectal tumour xenografts to 7 cytotoxic agents have been established. Tumour responses have been…
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1978
1978
Chemotherapy of gynecologic cancer with nitrosoureas: a randomized trial of CCNU and methyl-CCNU in cancers of the cervix, corpus, vagina, and vulva.
G. Omura
,
H. Shingleton
,
W. Creasman
,
J. Blessing
,
R. Boronow
Cancer treatment reports
1978
Corpus ID: 5913534
1976
1976
A comparative clinical trial evaluating the combination of adriamycin, DTIC, and vincristine, the combination of actinomycin D, cyclophosphamide, and vincristine, and a single agent, methyl-CCNU, in…
E. Creagan
,
R. Hahn
,
D. Ahmann
,
J. Edmonson
,
H. F. Bisel
,
R. Eagan
Cancer treatment reports
1976
Corpus ID: 42102515
1975
1975
Fat emulsion vehicle for intravenous administration of an aqueous insoluble drug.
C. Fortner
,
W. Grove
,
D. Bowie
,
M. D. Walker
American journal of hospital pharmacy
1975
Corpus ID: 31822875
Formulation of a sterile preparation for the parenteral administration of a water insoluble drug is described. Methyl CCNU was…
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