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Semustine

Known as: 1-(2-Chloroethyl)-3-(Trans-4-Methylcyclohexane)-1-Nitrosourea, Lomustine, methyl, Urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI) 
A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic… 
National Institutes of Health

Related topics

Related topics

25 relations

Broader (1)

Antineoplastic Agents, Alkylating

Narrower (8)

FAMMe protocolFME protocolFMI protocolFMT protocol
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2003
Review
2003
Radiochemotherapy of Malignant Glioma in Adults
Background: Standard treatment in patients with malignant glioma consists of surgery and postoperative radiotherapy. A high early… 
1988
1988
Adjuvant treatments following curative resection for gastric cancer
The results of a prospective randomized trial of adjuvant treatment after curative resection for gastric cancer are reported. The… 
Highly Cited
1980
Highly Cited
1980
Chemotherapy Programs of the National Prostatic Cancer Project (NPCP)
Results of the first nationally randomized trial of the National Prostatic Cancer Project revealed a demonstrable advantage for… 
Highly Cited
1978
Highly Cited
1978
DNA cross-linking by in vivo treatment with 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea of sensitive and resistant human colon carcinoma xenograms in nude mice.
The DNA alkaline elution technique provides a sensitive assay for the effects of DNA-damaging drugs in mammalian cells. We have… 
Highly Cited
1978
Highly Cited
1978
5FU infusion with mitomycin‐C versus 5FU infusion with methyl‐CCNU in the treatment of advanced colon cancer. A southwest oncology group study
The Southwest Oncology Group (SWOG) in a randomized trial evaluated 5FU infusions in combination with either Mitomycin‐C or… 
Highly Cited
1977
Highly Cited
1977
Results with methyl‐CCNU and DTIC in metastatic melanoma
This report is the result of an Eastern Cooperative Oncology Group (ECOG) study. Four hundred and 15 patients with inoperable… 
1977
1977
trans Fatty acid content of commercial margarine samples determined by gas liquid chromatography on OV- 275
Gas liquid chromatography (GLC) of margarine methyl esters on a 20 ft × 1/8 in. column containing 15% OV-275 on 100/120 mesh… 
Highly Cited
1975
Highly Cited
1975
COMB (cyclophosphamide, oncovin, methyl‐ccnu, and bleomycin): A four‐drug combination in solid tumors
One hundred eighty‐nine patients received a four‐drug combination consisting of cyclophosphamide, Oncovin (vincristine), methyl… 
Review
1975
Review
1975
Clinical comparison of the nitrosoureas
The nitrosourea group of antitumor agents was developed by the Division of Cancer Treatment of the National Cancer Institute… 
Highly Cited
1973
Highly Cited
1973
Initial clinical trials with methyl‐ccnu 1‐(2‐chloroethyl)‐3‐(4‐methyl cyclohexyl)‐1‐nitrosourea (meccnu)
Fifty patients have been treated with MeCCNU, 26 of whom received multiple doses at 6‐week intervals. The primary toxicity of… 
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