Skip to search formSkip to main contentSkip to account menu

Semustine

Known as: 1-(2-Chloroethyl)-3-(Trans-4-Methylcyclohexane)-1-Nitrosourea, Lomustine, methyl, Urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI) 
A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic… 
National Institutes of Health

Related topics

Related topics

25 relations

Broader (1)

Antineoplastic Agents, Alkylating

Narrower (8)

FAMMe protocolFME protocolFMI protocolFMT protocol
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
A phase I/II trial of PTK787/ZK 222584 (PTK/ZK), a novel, oral angiogenesis inhibitor, in combination with either temozolomide or lomustine for patients with recurrent glioblastoma multiforme (GBM).
1513 Background: VEGF-mediated signaling through VEGF receptors is integral to GBM neovascularization and therefore an attractive… 
Highly Cited
1983
Highly Cited
1983
Correlation between response to chemotherapy of human tumors in patients and in nude mice
Human tumors serially heterotransplanted in nude mice have been tested for their response to chemotherapeutic agents. Fourteen… 
Highly Cited
1980
Highly Cited
1980
Chemotherapy Programs of the National Prostatic Cancer Project (NPCP)
Results of the first nationally randomized trial of the National Prostatic Cancer Project revealed a demonstrable advantage for… 
Highly Cited
1979
Highly Cited
1979
Chronic renal failure in children treated with methyl CCNU.
METHYL CCNU (1- [2-chloroethyl] -3-[4-methyl cyclohexylj-1-nitrosourea) has been used to treat a variety of solid tumors1 2 3 for… 
Review
1978
Review
1978
Patterns of resistance and therapeutic synergism among alkylating agents.
Alkylating anticancer drugs are varied in chemical structure, alkylating moieties, and likely mechanisms of cytotoxic activity… 
Highly Cited
1977
Highly Cited
1977
Evaluation of single agents and combinations of chemotherapeutic agents in mouse colon carcinomas
Single agents and combinations of agents were tested for antitumor activity against four transplantable colon tumors in mice. The… 
Highly Cited
1977
Highly Cited
1977
Results with methyl‐CCNU and DTIC in metastatic melanoma
This report is the result of an Eastern Cooperative Oncology Group (ECOG) study. Four hundred and 15 patients with inoperable… 
Review
1975
Review
1975
Clinical comparison of the nitrosoureas
The nitrosourea group of antitumor agents was developed by the Division of Cancer Treatment of the National Cancer Institute… 
Highly Cited
1975
Highly Cited
1975
COMB (cyclophosphamide, oncovin, methyl‐ccnu, and bleomycin): A four‐drug combination in solid tumors
One hundred eighty‐nine patients received a four‐drug combination consisting of cyclophosphamide, Oncovin (vincristine), methyl… 
Highly Cited
1973
Highly Cited
1973
Initial clinical trials with methyl‐ccnu 1‐(2‐chloroethyl)‐3‐(4‐methyl cyclohexyl)‐1‐nitrosourea (meccnu)
Fifty patients have been treated with MeCCNU, 26 of whom received multiple doses at 6‐week intervals. The primary toxicity of… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)