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Semustine
Known as:
1-(2-Chloroethyl)-3-(Trans-4-Methylcyclohexane)-1-Nitrosourea
, Lomustine, methyl
, Urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI)
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A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic…
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National Institutes of Health
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Related topics
Related topics
25 relations
Broader (1)
Antineoplastic Agents, Alkylating
Narrower (8)
FAMMe protocol
FME protocol
FMI protocol
FMT protocol
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In Blood
NCIt Antineoplastic Agent Terminology
agonists
analogs & derivatives
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
1995
Review
1995
Review of adjuvant chemotherapy for gastric cancer
T. Nakajima
World Journal of Surgery
1995
Corpus ID: 6499004
Controlled randomized studies that compared surgery alone to adjuvant chemotherapy for gastric cancer were reviewed. The amount…
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1990
1990
The quest for a predictive design of anticancer drugs
G. Sosnovsky
1990
Corpus ID: 53542406
Abstract
1989
1989
Degradation and disposal of some antineoplastic drugs.
G. Lunn
,
Eric B. Sansone
,
A. W. Andrews
,
L. Hellwig
Journal of Pharmacy and Science
1989
Corpus ID: 30383855
Bulk quantities and pharmaceutical preparations of the antineoplastic drugs carmustine (BCNU), lomustine (CCNU), chlorozotocin, N…
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1983
1983
Nephrotoxicity of semustine.
Weiss Rb
,
Posada Jg
,
Kramer Ra
,
Boyd Mr
1983
Corpus ID: 78005378
: Semustine is an investigational cancer chemotherapeutic agent in widespread use. This agent has now been documented to produce…
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1980
1980
Comparison of two combination chemotherapy regimens for multiple myeloma: methyl-CCNU, cyclophosphamide, and prednisone versus melphalan and prednisone.
F. Cavagnaro
,
J. Lein
,
+7 authors
M. Pizzolato
Cancer treatment reports
1980
Corpus ID: 22625242
Of 139 evaluable and previously untreated patients with multiple myeloma, 67 received methyl-CCNU-cyclophosphamide-prednisone…
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1979
1979
Biologic activity of MCNU: a new antitumor agent.
S. Sekido
,
K. Ninomiya
,
M. Iwasaki
Cancer treatment reports
1979
Corpus ID: 36228674
A novel nitrosourea derivative, methyl-6-[[[(2-chloroethyl)nitrosoamino]carbonyl]-amino]-6-deoxy-alpha-D-glucopyranoside (MCNU…
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1979
1979
Phase II-III chemotherapy studies in advanced gastric cancer. Eastern Cooperative Oncology Group.
C. Moertel
,
P. Lavin
Cancer treatment reports
1979
Corpus ID: 7455362
In this study, 139 eligible and evaluable patients with advanced gastric cancer, measurable disease, and no prior chemotherapy…
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1977
1977
Qualitative and quantitative toxicity of sublethal doses of methyl-CCNU in BDF1 mice.
Denine Ep
,
Harrison Sd
,
Peckham Jc
1977
Corpus ID: 99356273
1975
1975
Fat emulsion vehicle for intravenous administration of an aqueous insoluble drug.
C. Fortner
,
W. Grove
,
D. Bowie
,
M. D. Walker
American journal of hospital pharmacy
1975
Corpus ID: 31822875
Formulation of a sterile preparation for the parenteral administration of a water insoluble drug is described. Methyl CCNU was…
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1975
1975
The oncostatic and immunosuppressive action of new nitrosourea derivatives containing sugar radicals.
J. Imbach
,
J. Montero
,
+4 authors
G. Mathé
Biomedicine / [publiee pour l'A.A.I.C.I.G.]
1975
Corpus ID: 29757869
Four new nitrosourea derivatives represent an appreciable progress in the treatment and cure of L1210 leukemia. Their therapeutic…
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