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During somite development, a fibroblast growth factor (FGF) signal secreted from the myotome induces formation of a scleraxis… Expand Sonic hedgehog (Shh) signaling is essential for sclerotome development in the mouse. Gli2 and Gli3 are thought to be the primary… Expand The paralogous genes Pax1 and Pax9 constitute one group within the vertebrate Pax gene family. They encode closely related… Expand The most profound feature of the mature vertebrate somite is its organisation into dorsal dermomyotome, intermediate myotome and… Expand We isolated a murine homeobox containing gene, Uncx4.1. The homeodomain sequence exhibits 88% identity to the unc‐4 protein at… Expand An early step in the development of vertebrae, ribs, muscle, and dermis is the differentiation of the somitic mesoderm into… Expand Previous studies have identified a single amino-acid substitution in the transcriptional regulator Pax-1 as the cause of the… Expand Somites are mesodermal structures which appear transiently in vertebrates in the course of their development. Cells situated… Expand Melorheostosis is characterised radiologically by hyperostotic linear densities in bone. These densities have a peculiarly… Expand The development of the sclerotome is considered as a model for the formation of mesenchyme from an epithelium. In early… Expand