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Sclerostin

Sclerostin (213 aa, ~24 kDa) is encoded by the human SOST gene. This protein plays a role in the regulation of bone growth and Wnt signaling pathways… 
National Institutes of Health

Related topics

Related topics

8 relations
Environment-to-Cell CommunicationExtracellular SpaceSOST geneSclerostin Measurement

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Clearance of Sclerostin, Osteocalcin, Fibroblast Growth Factor 23, and Osteoprotegerin by Dialysis
Introduction: Fibroblast growth factor (FGF23), sclerostin, osteocalcin, and osteoprotegerin are important factors that control… 
2017
2017
Sclerostin and energy metabolism during physical activity
2017
2017
Radial artery sclerostin expression in chronic kidney disease stage 5 predialysis patients: a cross-sectional observational study
PurposeBone metabolism disorder is often associated with cardiovascular calcification in patients with chronic kidney disease… 
2017
2017
Higher serum sclerostin levels and insufficiency of vitamin D are strongly associated with vertebral fractures in hemodialysis patients: a case control study
SummaryIn hemodialysis patients, vertebral fractures were associated with elevated sclerostin levels, suggesting that sclerostin… 
2017
2017
Romosozumab Treatment Converts Trabecular Rods into Trabecular Plates in Male Cynomolgus Monkeys
Treatment with sclerostin antibody (romosozumab) increases bone formation while reducing bone resorption, leading to increases in… 
2016
2016
Treatment with cinacalcet increases plasma sclerostin concentration in hemodialysis patients with secondary hyperparathyroidism
BackgroundSclerostin is a paracrine acting factor, which is expressed in the osteocytes and articular chondrocytes. Sclerostin… 
2015
2015
Factors associated with serum soluble inhibitors of Wnt‐β‐catenin signaling (sclerostin and dickkopf‐1) in patients undergoing peritoneal dialysis
Sclerostin and dickkopf‐1 (Dkk‐1) are soluble inhibitors of Wnt‐β‐catenin signaling and are involved in decreased bone formation… 
2014
2014
The regulation of the sclerostin gene and the catabolic effects of sclerostin protein on bone.
Sclerostin is a product of mature osteocytes embedded in mineralised bone and is a negative regulator of bone mass and osteoblast… 
Review
2014
Review
2014
Future directions for new medical entities in osteoporosis.
Review
2013
Review
2013
Osteocytes: Regulating the Mineral Reserves?
Osteocytes are increasingly recognized as multifunctional cells that help orchestrate bone and mineral metabolism— and are… 
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