SOST gene

Known as: VBCH, SCLEROSTIN, Sclerostin Gene 
This gene plays a role in bone growth.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Sclerostin, the Wnt signaling antagonist encoded by the Sost gene, is secreted by osteocytes and inhibits bone formation by… (More)
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Highly Cited
2008
Highly Cited
2008
Sclerostin, the protein product of the Sost gene, is a potent inhibitor of bone formation. Among bone cells, sclerostin is found… (More)
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Highly Cited
2008
Highly Cited
2008
INTRODUCTION Sclerosteosis is a rare high bone mass genetic disorder in humans caused by inactivating mutations in SOST, the gene… (More)
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Highly Cited
2006
Highly Cited
2006
The low density lipoprotein (LDL) receptor-related protein 5 (LRP5) is a co-receptor for Wnt proteins and a major regulator in… (More)
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Highly Cited
2005
Highly Cited
2005
Intermittent parathyroid hormone (PTH) application is an established pharmacological principle to stimulate bone formation. Yet… (More)
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Highly Cited
2005
Highly Cited
2005
The loss of the SOST gene product sclerostin leads to sclerosteosis characterized by high bone mass. In this report, we found… (More)
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Review
2005
Review
2005
Sclerosteosis and Van Buchem disease are two closely related bone disorders characterized by progressive bone thickening due to… (More)
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Highly Cited
2003
Highly Cited
2003
There is an unmet medical need for anabolic treatments to restore lost bone. Human genetic bone disorders provide insight into… (More)
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Highly Cited
2002
Highly Cited
2002
Van Buchem disease is an autosomal recessive skeletal dysplasia characterised by generalised bone overgrowth, predominantly in… (More)
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Highly Cited
2001
Highly Cited
2001
Sclerosteosis is a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is… (More)
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