Sch 42427

Known as: Sch-42427 
 
National Institutes of Health

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Broader (1)

Sch 39304

Papers overview

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2002
2002
Pharmacokinetics of the active antifungal enantiomer, SCH 42427 (RR), and evaluation of its chiral inversion in animals following its oral administration and the oral administration of its racemate…
Genaconazole (SCH 39304) is a potent triazole antifungal agent that is active both orally and topically. Genaconazole is a… Expand
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1995
1995
Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring.
A series of azole derivatives carrying an N-acylmorpholine ring are described. The compounds were chemically designed to simulate… Expand
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1994
1994
Treatment of murine pulmonary mucormycosis with SCH 42427, a broad-spectrum triazole antifungal drug.
 
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1993
1993
Effect of anti-IL-4, interferon-gamma and an antifungal triazole (SCH 42427) in paracoccidioidomycosis: correlation of IgE levels with outcome.
Paracoccidioidomycosis is characterized by depressed cellular but enhanced humoral immune responses, which suggests a Th2 type of… Expand
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1993
1993
Relationship Among Physicochemical Properties, Skin Permeability, and Topical Activity of the Racemic Compound and Pure Enantiomers of a New Antifungal
The topical antifungal Sch-39304 is a racemic compound comprised of two enantiomers, Sch-42427 and Sch-42426, only one of which… Expand
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1992
1992
Effect of cyclodextrin on the pharmacology of antifungal oral azoles.
Concentrations of oral azoles in serum were compared in a single-dose pharmacologic study in mice. When hydroxypropyl-beta… Expand
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1992
1992
In vitro and in vivo activities of SCH 42427, the active enantiomer of the antifungal agent SCH 39304.
SCH 39304, a new triazole antifungal agent, is a 50:50 racemic mixture of two enantiomers, SCH 42427 and SCH 42426. The… Expand
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1992
1992
Comparison of SCH 39304 and its isomers, RR 42427 and SS 42426, for treatment of murine cryptococcal and coccidioidal meningitis.
SCH 39304 (304) and its isomers, SCH 42426 (426) and SCH 42427 (427), are new orally administered antifungal azole derivatives… Expand
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Review
1992
Review
1992
Experimental antifungal chemotherapy in granulocytopenic animal models of disseminated candidiasis: approaches to understanding investigational antifungal compounds for patients with neoplastic…
Disseminated candidiasis is the most common life-threatening invasive fungal infection in granulocytopenic patients. A review of… Expand
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