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Sch 42427
Known as:
Sch-42427
National Institutes of Health
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Sch 39304
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Relationship Among Physicochemical Properties, Skin Permeability, and Topical Activity of the Racemic Compound and Pure Enantiomers of a New Antifungal
L. Wearley
,
B. Antonacci
,
+9 authors
T. Yarosh-Tomaine
Pharmaceutical Research
2004
Corpus ID: 2703803
The topical antifungal Sch-39304 is a racemic compound comprised of two enantiomers, Sch-42427 and Sch-42426, only one of which…
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2002
2002
Pharmacokinetics of the active antifungal enantiomer, SCH 42427 (RR), and evaluation of its chiral inversion in animals following its oral administration and the oral administration of its racemate…
Hong Kim
,
E. Radwanski
,
R. Lovey
,
Chin‐chung Lin
,
A. Nomeir
Chirality
2002
Corpus ID: 2524434
Genaconazole (SCH 39304) is a potent triazole antifungal agent that is active both orally and topically. Genaconazole is a…
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1995
1995
Synthesis and antifungal activity of new azole derivatives containing an N-acylmorpholine ring.
J. Bartrolí
,
E. Turmo
,
+4 authors
J. Forn
Journal of Medicinal Chemistry
1995
Corpus ID: 22012205
A series of azole derivatives carrying an N-acylmorpholine ring are described. The compounds were chemically designed to simulate…
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1994
1994
Treatment of murine pulmonary mucormycosis with SCH 42427, a broad-spectrum triazole antifungal drug.
L. Goldani
,
A. Sugar
Journal of Antimicrobial Chemotherapy
1994
Corpus ID: 19772692
1993
1993
Effect of anti‐IL‐4, interferon‐gamma and an antifungal triazole (SCH 42427) in paracoccidioidomycosis: correlation of IgE levels with outcome
J. S. Hostetler
,
E. Brummer
,
R. Coffman
,
D. Stevens
Clinical and Experimental Immunology
1993
Corpus ID: 24272591
Paracoccidioidomycosis is characterized by depressed cellular but enhanced humoral immune responses, which suggests a Th2 type of…
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Highly Cited
1992
Highly Cited
1992
Effect of cyclodextrin on the pharmacology of antifungal oral azoles
J. S. Hostetler
,
L. H. Hanson
,
D. Stevens
Antimicrobial Agents and Chemotherapy
1992
Corpus ID: 36700514
Concentrations of oral azoles in serum were compared in a single-dose pharmacologic study in mice. When hydroxypropyl-beta…
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1992
1992
In vitro and in vivo activities of SCH 42427, the active enantiomer of the antifungal agent SCH 39304
D. Loebenberg
,
A. Cacciapuoti
,
+7 authors
G. Miller
Antimicrobial Agents and Chemotherapy
1992
Corpus ID: 11701022
SCH 39304, a new triazole antifungal agent, is a 50:50 racemic mixture of two enantiomers, SCH 42427 and SCH 42426. The…
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Review
1992
Review
1992
Experimental antifungal chemotherapy in granulocytopenic animal models of disseminated candidiasis: approaches to understanding investigational antifungal compounds for patients with neoplastic…
T. Walsh
,
J. Lee
,
+4 authors
P. Pizzo
Clinical Infectious Diseases
1992
Corpus ID: 45589445
Disseminated candidiasis is the most common life-threatening invasive fungal infection in granulocytopenic patients. A review of…
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1992
1992
Comparison of SCH 39304 and its isomers, RR 42427 and SS 42426, for treatment of murine cryptococcal and coccidioidal meningitis
R. Allendoerfer
,
R. R. Yates
,
A. Marquis
,
D. Loebenberg
,
M. Rinaldi
,
J. Graybill
Antimicrobial Agents and Chemotherapy
1992
Corpus ID: 23114111
SCH 39304 (304) and its isomers, SCH 42426 (426) and SCH 42427 (427), are new orally administered antifungal azole derivatives…
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