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Sarin

Known as: ortho Isopropylmethyl Phosphonofluoridate, o-Isopropylmethyl Phosphonofluoridate, Phosphonofluoridic acid, methyl-, 1-methylethyl ester 
An organophosphorus ester compound that produces potent and irreversible inhibition of cholinesterase. It is toxic to the nervous system and is a… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (3)

Chemical Warfare AgentsCholinesterase InhibitorsNerve Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (2)

crotylsarinethylsarin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Why does the G117H mutation considerably improve the activity of human butyrylcholinesterase against sarin? Insights from quantum mechanical/molecular mechanical free energy calculations.
Human butyrylcholinesterase (BChE) is recognized as the most promising bioscavenger for organophosphorus (OP) warfare nerve… 
2002
2002
Differentiating the Threat of Chemical and Biological Terrorism: Motivations and Constraints1
There is a heightened concern in the United States over the specter of a catastrophic domestic chemical or biological terrorist… 
2001
2001
A fine set of threads
Ultra-thin fibres spun from polymers could be used to protect against chemical weapons, dress wounds and make brakes for aircraft… 
1995
1995
Blood purification for severe sarin poisoning after the Tokyo subway attack.
To the Editor. —The terrorist attack using the nerve gas sarin that took place in the Tokyo subways on March 20, 1995, injured… 
1993
1993
A finite element model of the pedestrian knee-joint in lateral impact
This paper presents a modelling of a human knee joint in lateral impact for use in an explicit finite element code. The… 
1990
1990
An experimental evaluation of the descriptive validity of lottery-dependent utility theory
This article compares the performance of the expected utility (EU) and lottery-dependent expected utility (LDEU) models in… 
1959
1959
The effects of sarin and atropine on the respiratory center and neuromuscular junctions of the rat.
Records were made of the contractions of a slip of diaphragm muscle which was isolated from the circulation of the rat, while the… 
1956
1956
Kinetics of the enzymatic hydrolysis of sarin.
The enzymatic hydrolysis of sarin is apparently a single first-order reaction. There is no evidence of different reaction rates… 
1956
1956
The enzymatic hydrolysis products of sarin.
The hydrolysis of the powerful cholinesterase inhibitor, sarin, by a rat serum enzyme leads almost exclusively to isopropyl… 
1954
1954
Observations on Pharmacology of the Anticholinesterases Sarin and Tabun
  • S. KropA. Kunkel
  • Proceedings of the Society for Experimental…
  • 1954
  • Corpus ID: 37769567
Summary The phosphate esters sarin and tabun, potent anticholinesterase compounds, exert profound effects on the respiration… 
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